Diffuse tenosynovial giant cell tumor of the knee

Case contributed by Ashesh Ishwarlal Ranchod
Diagnosis probable

Presentation

Chronic left knee pain and limited range of motion. Negative trauma.

Patient Data

Age: 40 years
Gender: Female

There are no acute bony abnormalities present. There is a suprapatellar effusion. There is developing patellofemoral osteoarthritis with osteophytic spurring. The joint spaces are maintained.

Diffuse, multifocal, and irregular, synovial thickening and proliferation give rise to a villonodular appearance. This involves the anterior and posterior joint recesses, supra and infrapatellar including the popliteal bursae. There is a large joint effusion and a moderate, intact, popliteal cyst. There are extensive bone erosions, best visualized on the coronal T1 sequence. These are poorly appreciated in plain films but post-MRI review, are present. There is hemosiderin deposition as evidenced by the blooming on the T2* GRE.

There is incidental mucoid degeneration of the anterior cruciate ligament (ACL).

Case Discussion

As demonstrated, features suggest a diffuse tenosynovial giant cell tumor of the knee (previously called pigmented villonodular synovitis or PVNS).

The broad differential diagnosis includes:

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