Articles

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337 results found
Article

Thymic rebound hyperplasia

Thymic rebound hyperplasia is considered a form of true thymic hyperplasia. Pathology In periods of bodily stress the thymus may acutely shrink to 40% of its original volume (depending on the severity and duration of the stress). During the recovery phase it can grow back to its original size ...
Article

Leukostasis

Leukostasis, also known as symptomatic hyperleukocytosis, is a medical emergency in patients with leukemia, particularly acute myeloid leukemia (AML) and in the blast phase of chronic myeloid leukemia (CML), characterized by the over-accumulation of leukemic cells within the small vessels. Altho...
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Primary cutaneous lymphoma

Primary cutaneous lymphomas represent a group of extranodal non-Hodgkin lymphomas (T- or B-cell) primarily confined to the skin with no evidence of extracutaneous disease at the time of diagnosis (cf. secondary involvement of the skin).  Mycosis fungoides is the most prevalent type of primary c...
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CNS lymphoma

CNS lymphoma refers to the involvement of the central nervous system with lymphoma. It can be broadly divided into primary and secondary, with a number of special types also recognized.  primary lymphomas of the CNS primary diffuse large B-cell lymphoma of the CNS immunodeficiency-associated ...
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Secondary pulmonary lymphoma

Secondary pulmonary lymphomas refer to pulmonary involvement with lymphoma when the condition is not limited to the lung and has mediastinal lymph node involvement or evidence of extrathoracic dissemination for at least three months after the initial diagnosis. This is a more common form of pulm...
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Mantle cell lymphoma

Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma (NHL) and accounts for ~5% of all NHL. It is a malignant neoplasm of virgin B cells that closely resemble normal mantle zone B cells surrounding germinal centers. Epidemiology They occur in older adults (mean age ~60 years), and ther...
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Splenic pseudocyst

Splenic pseudocysts, also known as secondary splenic cysts, are acquired cystic lesions not delineated by a true epithelial wall. They represent the majority of the splenic cystic lesions, corresponding to approximately 80% of them (cf. splenic epithelial cysts). The main causes are:  splenic t...
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Splenic cyst

Splenic epithelial cysts, also known as splenic epidermoid cysts or primary splenic cysts, are unilocular fluid lesions with thin and smooth walls and no enhancement. They represent ~20% of cysts found in the spleen and are usually an innocuous incidental imaging finding. Note that most (~80%) ...
Article

Splenic biopsy

Percutaneous splenic biopsy, using either ultrasound or CT guidance, is an accurate and reliable method of acquiring splenic tissue for histopathological assessment and has been proposed as an alternative for splenectomy in selected patients. Although the procedure has been historically feared ...
Article

Lederer-Brill disease

Lederer-Brill disease is a transient autoimmune hemolytic anemia with very variable clinical features 1. Epidemiology Lederer-Brill disease is slightly more prevalent in females 1. Clinical presentation It usually occurs in children with a recent history of infection. Symptoms and signs incl...
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Ann Arbor staging system (historical)

The Ann Arbor staging system was the landmark lymphoma staging classification system for both Hodgkin lymphoma and non-Hodgkin lymphoma. It is named after the town of Ann Arbor in the US state of Michigan where the Committee on Hodgkin's Disease Staging Classification met in 1971 to agree on it....
Article

Evans syndrome

Evans syndrome is an autoimmune condition with two or more cytopenias, usually caused by autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP), with or without immune neutropenia. Epidemiology Evans syndrome is considered rare, with defining bicytopenias present in less than 5% ...
Article

Bone marrow

Bone marrow is ubiquitous throughout the skeleton, primarily composed of hematopoietic cells and fat cells between bony trabeculae and fibrous retinacula. It performs numerous physiological functions and dynamically changes during normal aging and in response to stressors and pathology. Although...
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Hemorrhagic shock and encephalopathy syndrome

Hemorrhagic shock and encephalopathy syndrome (HSES) is a rare pediatric encephalopathy syndrome with a high mortality rate. Epidemiology Hemorrhagic shock and encephalopathy syndrome is considered rare, although the exact global incidence and prevalence is not known. The condition occurs in i...
Article

Gallbladder lymphoma

Gallbladder lymphoma is exceedingly rare and presents diagnostic challenges due to its imaging characteristics often resembling those of gallbladder adenocarcinoma. Epidemiology Primary lymphomas of the gallbladder are extremely rare, accounting for approximately 0.1-0.2% of all malignant tumo...
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Lymph node imaging

Lymph node imaging is a useful technique, aiding the clinician in determining whether nodes are benign or malignant. Multiple modalities are used for the assessment and characterization of lymph nodes, each with its advantages and drawbacks. Modalities Ultrasound size  number shape contour...
Article

Neurolymphomatosis

Neurolymphomatosis is a rare cause of neuropathy due to infiltration of the peripheral nervous system by a hematologic malignancy, in the great majority a B-cell non-Hodgkin lymphoma. It should be differentiated from non-tumor neuropathies associated with lymphoma, such as irradiation, chemothe...

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