14-3-3 protein
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14-3-3 protein is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic Creutzfeldt-Jakob disease (sCJD).
In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and theits specificity is 80% 1. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.
Results need to be correlated with the patient's history as CSF 14-3-3 can be false positive in acute stroke, encephalitis, and other dementias 1.
-<p><strong>14-3-3 protein </strong>is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic <a href="/articles/creutzfeldt-jakob-disease">Creutzfeldt-Jakob disease</a> (sCJD). </p><p>In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and the specificity is 80% <sup>1</sup>. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.</p><p>Results need to be correlated with patient's history as CSF 14-3-3 can be false positive in acute <a href="/articles/ischaemic-stroke">stroke</a>, <a href="/articles/encephalitis">encephalitis</a>, and other dementias <sup>1</sup>.</p>- +<p><strong>14-3-3 protein </strong>is found in the cerebrospinal fluid (CSF), and is currently used to help identify patients with sporadic <a href="/articles/creutzfeldt-jakob-disease">Creutzfeldt-Jakob disease</a> (sCJD). </p><p>In diagnosing sCJD, the sensitivity of 14-3-3 protein is 92% and its specificity is 80% <sup>1</sup>. A negative 14-3-3 assay may be helpful in reducing the suspicion of sCJD.</p><p>Results need to be correlated with the patient's history as CSF 14-3-3 can be false positive in acute <a href="/articles/ischaemic-stroke">stroke</a>, <a href="/articles/encephalitis">encephalitis</a>, and other dementias <sup>1</sup>.</p>
Sections changed:
- Pathology
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