Achondrogenesis 1A
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The Houston-Harris sub type or achondrogenesis type Ia is sub type of achondrogenesis. It is an extremely rare lethal skeletal dysplasia (chondrodysplasia) with a characteristic severe disarrangement of endochondral ossification.
Pathology
The growth plate cartilage completely lacks columnar-zone formation and shows chondrocyte expansion due to intracellular vacuoles.
Clinical spectrum
Some of the common clinical features include:
- low birth weight
- skeletal abnormalities
- very short limbs
- short neck
- incomplete ossification of bones - particularly the skull
- congenital cardiac anomalies
- breathing problems
- small chest
- underdeveloped lungs
- protruberant abdomen
See also
-
achondrogenesis
- type I :
- type Ia : Houston-Harris sub type
- type Ib : Parenti-Fraccaro sub type
- type II : Langer-Saldino syndrome
- type I :
-<p>The <strong>Houston-Harris sub type </strong>or <strong>achondrogenesis type Ia </strong>is sub type of <a href="/articles/achondrogenesis">achondrogenesis</a>. It is an extremely rare lethal <a href="/articles/skeletal-dysplasia">skeletal dysplasia</a> (chondrodysplasia) with a characteristic severe disarrangement of <a title="Endochondral ossification" href="/articles/endochondral-ossification">endochondral ossification</a>. </p><h4>Pathology</h4><p>The growth plate cartilage completely lacks columnar-zone formation and shows chondrocyte expansion due to intracellular vacuoles. </p><h4>Clinical spectrum</h4><p>Some of the common clinical features include :</p><ul>- +<p>The <strong>Houston-Harris sub type </strong>or <strong>achondrogenesis type Ia </strong>is sub type of <a href="/articles/achondrogenesis">achondrogenesis</a>. It is an extremely rare lethal <a href="/articles/skeletal-dysplasia">skeletal dysplasia</a> (chondrodysplasia) with a characteristic severe disarrangement of <a href="/articles/endochondral-ossification">endochondral ossification</a>. </p><h4>Pathology</h4><p>The growth plate cartilage completely lacks columnar-zone formation and shows chondrocyte expansion due to intracellular vacuoles. </p><h4>Clinical spectrum</h4><p>Some of the common clinical features include:</p><ul>
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