Question 547
{"accessible":false,"alternatives":[{"id":2742,"text":"adenocarcinoma"},{"id":2743,"text":"ascites"},{"id":2744,"text":"diabetes"},{"id":2745,"text":"gallstones"},{"id":2746,"text":"hypoalbuminemia"}],"archived":false,"correctAlternativeId":2745,"explanation":"\u003cp\u003e90-95% of cases are due to gallstones (i.e.\u0026nbsp;\u003cstrong\u003eacute calculous cholecystitis\u003c/strong\u003e) with the remainder being\u0026nbsp;\u003ca href=\"https://radiopaedia.org/articles/acute-acalculous-cholecystitis\"\u003eacute acalculous cholecystitis\u003c/a\u003e.\u003c/p\u003e\u003cp\u003eThe development of acute calculous cholecystitis follows a sequence of events:\u003c/p\u003e\u003col\u003e\n\u003cli\u003e\n\u003ca href=\"https://radiopaedia.org/articles/gallstones-1\"\u003egallstone\u003c/a\u003e\u0026nbsp;obstruction of the gallbladder neck or cystic duct\u003c/li\u003e\n\u003cli\u003einflammation from chemical injury of the mucosa by bile salts\u003c/li\u003e\n\u003cli\u003ereactive production of mucus,\u0026nbsp;leading to increased intraluminal pressure and distention\u003c/li\u003e\n\u003cli\u003eincreased luminal distention restricting blood flow to the gallbladder wall (\u003ca href=\"https://radiopaedia.org/articles/gallbladder-hydrops\"\u003egallbladder hydrops\u003c/a\u003e)\u003c/li\u003e\n\u003cli\u003eincreasing wall thickness from edema and inflammatory changes\u003c/li\u003e\n\u003cli\u003esecondary bacterial infection in ~66% of patients\u003c/li\u003e\n\u003c/ol\u003e","id":547,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2060","nextQuestionPath":"/articles/acute-cholecystitis/questions/425","relatedArticles":[],"alsoUsedIn":[],"stem":"\u003cp\u003eWhat is the most common cause of acute cholecystitis?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/547"}],"attemptsPercentages":[{"alternativeId":"2742","percentage":1},{"alternativeId":"2745","percentage":96},{"alternativeId":"2744","percentage":2},{"alternativeId":"2746","percentage":1},{"alternativeId":"2743","percentage":0}],"promptToLogin":false,"questionManager":false,"articleId":"acute-cholecystitis"}