Adenocarcinoma in situ of the lung
Updates to Article Attributes
AdenocarcinomaAdenocarcinomas in situ (AIS) of the lung refersrefer to a relatively new entity for a pre-invasive lesion in the lung. This entity partly replaces the noninvasive end of the previous term bronchoalveolar carcinoma. Adenocarcinoma in situ is defined as a localised adenocarcinoma of <3 cm that exhibits a lepidic growth pattern, with neoplastic cells along the alveolar structures but without stromal, vascular, or pleural invasion 1.
Radiographic features
CT
While adenocarcinoma in situ is usually seen as a pure ground-glass nodule or a part-solid lung nodule, there can be is an overlap among the imaging features of atypical adenomatous hyperplasia, adenocarcinoma in situ, and invasive adenocarcinoma of the lung 1.
Nuclear medicine
FDG PET-CT
Adenocarcinomas in situ are commonly associated with PET false-negative results. FDG PET/CT is recommended when assessing subsolid ground-glass lung lesions that have a solid component measuring more than 8 mm 5.
Treatment and prognosis
Adenocarcinoma in situ carries an excellent prognosis, with reported survival rates of 100% following complete tumour resection.
-<p><strong>Adenocarcinoma in situ (AIS) of the lung</strong> refers to a relatively new entity for a pre-invasive lesion in the lung. This entity partly replaces the noninvasive end of the previous term <a href="/articles/adenocarcinoma-in-situ-minimally-invasive-adenocarcinoma-and-invasive-adenocarcinoma-of-lung">bronchoalveolar carcinoma</a>. Adenocarcinoma in situ is defined as a localised adenocarcinoma of <3 cm that exhibits a lepidic growth pattern, with neoplastic cells along the alveolar structures but without stromal, vascular, or pleural invasion <sup>1</sup>.</p><h4>Radiographic features</h4><h5>CT</h5><p>While adenocarcinoma in situ is usually seen as a pure <a href="/articles/ground-glass-density-nodule">ground-glass nodule</a> or a <a href="/articles/part-solid-lung-nodule">part-solid lung nodule</a>, there can be is an overlap among the imaging features of <a href="/articles/atypical-adenomatous-hyperplasia-of-the-lung">atypical adenomatous hyperplasia</a>, adenocarcinoma in situ, and <a href="/articles/adenocarcinoma-of-the-lung">invasive adenocarcinoma of the lung</a> <sup>1</sup>.</p><h4>Treatment and prognosis</h4><p>Adenocarcinoma in situ carries an excellent prognosis, with reported survival rates of 100% following complete tumour resection.</p>- +<p><strong>Adenocarcinomas in situ of the lung</strong> refer to a relatively new entity for a pre-invasive lesion in the lung. This entity partly replaces the noninvasive end of the previous term <a href="/articles/adenocarcinoma-in-situ-minimally-invasive-adenocarcinoma-and-invasive-adenocarcinoma-of-lung">bronchoalveolar carcinoma</a>. Adenocarcinoma in situ is defined as a localised adenocarcinoma of <3 cm that exhibits a lepidic growth pattern, with neoplastic cells along the alveolar structures but without stromal, vascular, or pleural invasion <sup>1</sup>.</p><h4>Radiographic features</h4><h5>CT</h5><p>While adenocarcinoma in situ is usually seen as a pure <a href="/articles/ground-glass-density-nodule-1">ground-glass nodule</a> or a <a href="/articles/part-solid-lung-nodule">part-solid lung nodule</a>, there can be an overlap among the imaging features of <a href="/articles/atypical-adenomatous-hyperplasia-of-the-lung">atypical adenomatous hyperplasia</a>, adenocarcinoma in situ, and <a href="/articles/adenocarcinoma-of-the-lung">invasive adenocarcinoma of the lung</a> <sup>1</sup>.</p><h5>Nuclear medicine</h5><h6>FDG PET-CT</h6><p>Adenocarcinomas in situ are commonly associated with PET false-negative results. FDG PET/CT is recommended when assessing subsolid ground-glass lung lesions that have a solid component measuring more than 8 mm <sup>5</sup>. </p><h4>Treatment and prognosis</h4><p>Adenocarcinoma in situ carries an excellent prognosis, with reported survival rates of 100% following complete tumour resection.</p>
References changed:
- 5. Kandathil A, Kay FU, Butt YM, Wachsmann JW, Subramaniam RM. Role of FDG PET/CT in the Eighth Edition of TNM Staging of Non-Small Cell Lung Cancer. (2018) Radiographics : a review publication of the Radiological Society of North America, Inc. 38 (7): 2134-2149. <a href="https://doi.org/10.1148/rg.2018180060">doi:10.1148/rg.2018180060</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/30422775">Pubmed</a> <span class="ref_v4"></span>
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