Adrenal metastasis
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- updated 16 Jul 2022:
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Adrenal metastases are the most common malignant lesions involving the adrenal gland. Metastases are usually bilateral but may also be unilateral. Unilateral involvement is more prevalent on the left side (ratio of 1.5:1).
Epidemiology
They are present at autopsy in up to 27% of patients with known malignant epithelial tumours.
Pathology
Primary sites
Many primary tumours can potentially metastasise to the adrenal glands, commonly:
Other reported primary tumours include:
- renal cell carcinoma (RCC)
- hepatocellular carcinoma (HCC) 3
- malignant melanoma
- endometrial adenocarcinoma 7
- ovarian carcinoma 8
- prostatic cancer9
- gastric cancer 10
- cholangiocarcinoma 11
- oesophageal adenocarcinoma 12
- bladder carcinoma 13
- osteogenic osteosarcoma (rare) 14
- papillary thyroid carcinoma (rare)15
- testicular cancer 16
Radiographic features
CT
Adrenal metastases can have variable CT appearances 4. They usually demonstrate <50% washout.
In patients with RCC and HCC who undergo dedicated adrenal CT imaging for known adrenal lesions, the enhancement washout of adrenal metastases can be similar to that of lipid-poor adrenal adenomas. As hypervascular lesions, they commonly show intense enhancement on the portal venous phase, usually more than 120 HU, and thus can be easily identified.
MRI
Exact signal characteristics can vary depending on the type of tumour. In general, commonly described signal characteristics include:
- T1: usually exhibit low signal intensity 2
- T2: often show high signal intensity 2
- T1 C+ (Gd): usually has progressive enhancement after administration of contrast material 2
An important diagnostic feature is the lack of signal loss on out-of-phase images (in contradistinction to that seen with adrenal adenoma).
Practical points
- on CT, metastases usually demonstrate <50% washout
- if intense enhancement of >120 HU is identified in the portal venous phase, washout should be ignored, and a hypervascular lesion such as RCC or HCC metastasis should be considered as a primary
- MRI: no signal loss on out-of-phase images
-<p><strong>Adrenal metastases</strong> are the most common malignant lesions involving the <a href="/articles/adrenal-gland">adrenal gland</a>. Metastases are usually bilateral but may also be unilateral. Unilateral involvement is more prevalent on the left side (ratio of 1.5:1).</p><h4>Epidemiology</h4><p>They are present at autopsy in up to 27% of patients with known malignant epithelial tumours.</p><h4>Pathology</h4><h5>Primary sites</h5><p>Many primary tumours can potentially metastasise to the adrenal glands, commonly:</p><ul>-<li><a href="/articles/lung-cancer-3">lung cancer</a></li>-<li>-<a href="/articles/colorectal-cancer-1">colorectal carcinoma</a> </li>-<li><a href="/articles/breast-neoplasms">breast cancer</a></li>-<li>-<a href="/articles/pancreatic-neoplasms">pancreatic cancer</a> </li>-</ul><p>Other reported primary tumours include:</p><ul>-<li><a href="/articles/renal-cell-carcinoma-1">renal cell carcinoma (RCC)</a></li>-<li>-<a href="/articles/hepatocellular-carcinoma">hepatocellular carcinoma (HCC)</a> <sup>3</sup>-</li>-<li><a href="/articles/malignant-melanoma">malignant melanoma</a></li>-<li>-<a href="/articles/endometrial-carcinoma">endometrial adenocarcinoma</a> <sup>7</sup>-</li>-<li>-<a href="/articles/clear-cell-ovarian-carcinoma">ovarian carcinoma</a> <sup>8</sup>-</li>-<li>-<a href="/articles/prostate-cancer-staging-1">prostatic cancer</a><sup><a href="/articles/prostate-cancer-staging-1"> </a>9</sup>-</li>-<li>-<a href="/articles/gastric-cancer-summary">gastric cancer </a><sup>10</sup>-</li>-<li>-<a href="/articles/cholangiocarcinoma">cholangiocarcinoma </a><sup>11</sup>-</li>-<li>-<a href="/articles/siewert-stein-classification-of-oesophageal-adenocarcinoma">oesophageal adenocarcinoma</a> <sup>12</sup>-</li>-<li>-<a href="/articles/gallbladder-carcinoma-1">bladder carcinoma</a> <sup>13</sup>-</li>-<li>-<a href="/articles/osteosarcoma">osteogenic osteosarcoma</a> (rare) <sup>14</sup>-</li>-<li>-<a href="/articles/papillary-thyroid-cancer">papillary thyroid carcinoma</a> (rare)<sup>15</sup>-</li>-<li>-<a href="/articles/testicular-cancer">testicular cancer</a><sup> 16</sup>-</li>-</ul><h4>Radiographic features</h4><h5>CT</h5><p>Adrenal metastases can have variable CT appearances <sup>4</sup>. They usually demonstrate <50% washout.</p><p>In patients with RCC and HCC who undergo dedicated adrenal CT imaging for known adrenal lesions, the enhancement washout of adrenal metastases can be similar to that of lipid-poor adrenal adenomas. As hypervascular lesions, they commonly show intense enhancement on the portal venous phase, usually more than 120 HU, and thus can be easily identified. </p><h5>MRI</h5><p>Exact signal characteristics can vary depending on the type of tumour. In general, commonly described signal characteristics include:</p><ul>-<li>-<strong>T1:</strong> usually exhibit low signal intensity <sup>2</sup>-</li>-<li>-<strong>T2:</strong> often show high signal intensity <sup>2</sup>-</li>-<li>-<strong>T1 C+ (Gd):</strong> usually has progressive enhancement after administration of contrast material <sup>2</sup>-</li>-</ul><p>An important diagnostic feature is the lack of signal loss on <a href="/articles/in-phase-and-out-of-phase-sequences-1">out-of-phase images</a> (in contradistinction to that seen with adrenal adenoma).</p><h4>Practical points</h4><ul>-<li>on CT, metastases usually demonstrate <50% washout</li>-<li>if intense enhancement of >120 HU is identified in the portal venous phase, washout should be ignored, and a hypervascular lesion such as RCC or HCC metastasis should be considered as a primary</li>-<li>MRI: no signal loss on out-of-phase images</li>- +<p><strong>Adrenal metastases</strong> are the most common malignant lesions involving the <a href="/articles/adrenal-gland">adrenal gland</a>. Metastases are usually bilateral but may also be unilateral. Unilateral involvement is more prevalent on the left side (ratio of 1.5:1).</p><h4>Epidemiology</h4><p>They are present at autopsy in up to 27% of patients with known malignant epithelial tumours.</p><h4>Pathology</h4><h5>Primary sites</h5><p>Many primary tumours can potentially metastasise to the adrenal glands, commonly:</p><ul>
- +<li><a href="/articles/lung-cancer-3">lung cancer</a></li>
- +<li>
- +<a href="/articles/colorectal-cancer-1">colorectal carcinoma</a> </li>
- +<li><a href="/articles/breast-neoplasms">breast cancer</a></li>
- +<li>
- +<a href="/articles/pancreatic-neoplasms">pancreatic cancer</a> </li>
- +</ul><p>Other reported primary tumours include:</p><ul>
- +<li><a href="/articles/renal-cell-carcinoma-1">renal cell carcinoma (RCC)</a></li>
- +<li>
- +<a href="/articles/hepatocellular-carcinoma">hepatocellular carcinoma (HCC)</a> <sup>3</sup>
- +</li>
- +<li><a href="/articles/malignant-melanoma">malignant melanoma</a></li>
- +<li>
- +<a href="/articles/endometrial-carcinoma">endometrial adenocarcinoma</a> <sup>7</sup>
- +</li>
- +<li>
- +<a href="/articles/clear-cell-ovarian-carcinoma">ovarian carcinoma</a> <sup>8</sup>
- +</li>
- +<li>
- +<a href="/articles/prostate-cancer-staging-1">prostatic cancer</a><sup><a href="/articles/prostate-cancer-staging-1"> </a>9</sup>
- +</li>
- +<li>
- +<a href="/articles/gastric-cancer-summary">gastric cancer </a><sup>10</sup>
- +</li>
- +<li>
- +<a href="/articles/cholangiocarcinoma">cholangiocarcinoma </a><sup>11</sup>
- +</li>
- +<li>
- +<a href="/articles/siewert-stein-classification-of-oesophageal-adenocarcinoma">oesophageal adenocarcinoma</a> <sup>12</sup>
- +</li>
- +<li>
- +<a href="/articles/gallbladder-carcinoma-1">bladder carcinoma</a> <sup>13</sup>
- +</li>
- +<li>
- +<a href="/articles/osteosarcoma">osteogenic osteosarcoma</a> (rare) <sup>14</sup>
- +</li>
- +<li>
- +<a href="/articles/papillary-thyroid-cancer">papillary thyroid carcinoma</a> (rare)<sup>15</sup>
- +</li>
- +<li>
- +<a href="/articles/testicular-cancer">testicular cancer</a><sup> 16</sup>
- +</li>
- +</ul><h4>Radiographic features</h4><h5>CT</h5><p>Adrenal metastases can have variable CT appearances <sup>4</sup>. They usually demonstrate <50% washout.</p><p>In patients with RCC and HCC who undergo dedicated adrenal CT imaging for known adrenal lesions, the enhancement washout of adrenal metastases can be similar to that of lipid-poor adrenal adenomas. As hypervascular lesions, they commonly show intense enhancement on the portal venous phase, usually more than 120 HU, and thus can be easily identified. </p><h5>MRI</h5><p>Exact signal characteristics can vary depending on the type of tumour. In general, commonly described signal characteristics include:</p><ul>
- +<li>
- +<strong>T1:</strong> usually exhibit low signal intensity <sup>2</sup>
- +</li>
- +<li>
- +<strong>T2:</strong> often show high signal intensity <sup>2</sup>
- +</li>
- +<li>
- +<strong>T1 C+ (Gd):</strong> usually has progressive enhancement after administration of contrast material <sup>2</sup>
- +</li>
- +</ul><p>An important diagnostic feature is the lack of signal loss on <a href="/articles/in-phase-and-out-of-phase-sequences-1">out-of-phase images</a> (in contradistinction to that seen with adrenal adenoma).</p><h4>Practical points</h4><ul>
- +<li>on CT, metastases usually demonstrate <50% washout</li>
- +<li>if intense enhancement of >120 HU is identified in the portal venous phase, washout should be ignored, and a hypervascular lesion such as RCC or HCC metastasis should be considered as a primary</li>
- +<li>MRI: no signal loss on out-of-phase images</li>
Images Changes:
Image 12 CT (C+ portal venous phase) ( create )
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