Agatston score

Agatston score⁷ is a semi-automated tool to calculate a score based on the extent of coronary artery calcification detected by an unenhanced low-dose CT scan which is routinely performed in patients undergoing cardiac CT. Due to an extensive body of research, it allows for an early risk stratification as patients with a high Agatston score (>160) have an increased risk for a major adverse cardiac event (MACE) ². Although it does not allow for the assessment of soft non-calcified plaques, it has shown a good correlation with contrast-enhanced CT coronary angiography ¹. 

Method of calculation

The calculation is based on the weighted density score given to the highest attenuation value (HU) multiplied by area of the calcification speck.

Density factor:

• 130-199 HU: 1
• 200-299 HU: 2
• 300-399 HU: 3
• 400+ HU: 4

For example, if a calcified speck has maximum attenuation value of 400 HU and occupies 8 sq mm area, then its calcium score will be 32.

The score of every calcified speck is summed up to give the total calcium score.  

Grading of coronary artery disease (based on total calcium score)

• no evidence of CAD: 0 calcium score
• minimal: 1-10
• mild: 11-100
• moderate: 101-400
• severe: >400

Guidelines for coronary calcium scoring by 2010 ACCF task force.⁽⁴⁾

Intermediate

• intermediate cardiovascular risk and asymptomatic adults- Class IIA.

  Low to intermediate

  (class IIa)
• low-to-intermediate risk and asymptomatic adults-Class- IIB.

  Low

  (class IIb)
• low risk and asymptomatic-class (class III.

  Asymptomatic

  )
• asymptomatic adults with diabetes, 40 years of age and older- Class IIA. (class IIa)

Cardiovascular risk calculator.⁽⁵⁾

Many risk calculators are available. Framingham CVcardiovascular risk calculator uses age, gender, total cholesterol, HDL cholesterol, smoking history, systolic BP and if on medications for hypertensionblood pressure, and antihypertensive medication use ⁵.

Other calcium scoring methods

• volume calcium score
• calcium mass score