Question 1158
{"accessible":false,"alternatives":[{"id":5798,"text":"adrenal glands"},{"id":5799,"text":"kidneys"},{"id":5800,"text":"liver"},{"id":5801,"text":"lung"},{"id":5802,"text":"stomach"}],"archived":false,"correctAlternativeId":5800,"explanation":"\u003cp\u003eAlpha-1-antitrypsin (A1AT) is a protein that prevents enzymes such as elastase from degrading normal host tissue. Over 90% of the alpha-1-antitrypsin protein is produced in hepatocytes by codominant gene expression on chromosome 14.\u0026nbsp;The alpha-1-antitrypsin protein inhibits neutrophil elastase. In patients with severe deficiency, the neutrophil elastase acts unopposed resulting in damage to the lower respiratory tract. This damage is predominantly basal because of the gravitational distribution of pulmonary blood flow.\u003c/p\u003e","id":1158,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/1158","nextQuestionPath":"/articles/alpha-1-antitrypsin-deficiency-4/questions/1157","relatedArticles":[],"alsoUsedIn":[],"stem":"\u003cp\u003eAlpha-1-antitrypsin is produced in the...\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/1158"}],"attemptsPercentages":[{"alternativeId":"5800","percentage":68},{"alternativeId":"5799","percentage":2},{"alternativeId":"5801","percentage":24},{"alternativeId":"5802","percentage":3},{"alternativeId":"5798","percentage":3}],"promptToLogin":false,"questionManager":false,"articleId":"alpha-1-antitrypsin-deficiency"}