Question 463
{"accessible":false,"alternatives":[{"id":2322,"text":"500"},{"id":2323,"text":"750"},{"id":2324,"text":"1000"},{"id":2325,"text":"1500"},{"id":2326,"text":"2500"}],"archived":false,"correctAlternativeId":2323,"explanation":"\u003cp\u003eADC values are reproducible across different field strengths and manufacturers. \u003c/p\u003e\u003cp\u003eNormal white matter typically has values of around 750 x 10\u003csup\u003e-6\u003c/sup\u003e\u0026nbsp;mm\u003csup\u003e2\u003c/sup\u003e/s. \u003c/p\u003e\u003cp\u003eLow-grade gliomas will have facilitated diffusion e.g. 1200-1500 10\u003csup\u003e-6\u003c/sup\u003e\u0026nbsp;mm\u003csup\u003e2\u003c/sup\u003e/s.\u003c/p\u003e\u003cp\u003eHighly cellular tumors such as lymphoma, pineoblastoma and medulloblastoma will have low ADC values e.g. ~500 10\u003csup\u003e-6\u003c/sup\u003e\u0026nbsp;mm\u003csup\u003e2\u003c/sup\u003e/s.\u003c/p\u003e\u003cp\u003eIt is worth noting that the solid component of glioblastomas /grade 4 diffuse astrocytoma also typically has ADC values ~750 10\u003csup\u003e-6\u003c/sup\u003e\u0026nbsp;mm\u003csup\u003e2\u003c/sup\u003e/s. Thus, when we say that high grade tumors diffusion restrict, they only do so roughly as much as normal brain. \u003c/p\u003e","id":463,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2260","nextQuestionPath":"/articles/apparent-diffusion-coefficient-1/questions/460","relatedArticles":[{"id":62713,"title":"White matter","link":"/articles/white-matter?lang=us"}],"alsoUsedIn":[{"id":1230,"kind":"Course","title":"Enhancing Brain Tumours Learning Pathway - page 1230","link":"https://radiopaedia.org/courses/enhancing-brain-tumours-learning-pathway/pages/1230"},{"id":1230,"kind":"Course","title":"Brain Tumours Learning Pathway - page 1230","link":"https://radiopaedia.org/courses/brain-tumours-learning-pathway/pages/1230"}],"stem":"\u003cp\u003eWhat is the approximate expected apparent diffusion coefficient\u0026nbsp;(ADC; x 10\u003csup\u003e-6\u003c/sup\u003e\u0026nbsp;mm\u003csup\u003e2\u003c/sup\u003e/s) of normal white matter?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/463"}],"attemptsPercentages":[{"alternativeId":"2324","percentage":8},{"alternativeId":"2326","percentage":2},{"alternativeId":"2325","percentage":3},{"alternativeId":"2322","percentage":7},{"alternativeId":"2323","percentage":79}],"promptToLogin":false,"questionManager":false,"articleId":"apparent-diffusion-coefficient"}