Astrocytic tumors
Disclosures
- updated 4 Apr 2022:
- Radiopaedia Australia Pty Ltd, Founder and CEO (ongoing)
- Biogen Australia Pty Ltd, Investigator-Initiated Research Grant for CAD software development in multiple sclerosis (past)
Updates to Article Attributes
Body
was changed:
Astrocytic tumours are primary central nervous system tumours that either arises from astrocytes or appear similar to astrocytes on histology having arisen from precursor cells. They are the most common tumours arising from glial cells and can be broadly divided into three groups:
- diffuse, adult-type
- diffuse, paediatric type
- circumscribed
These can further be divided into individual entities (asas described in the WHO classification of CNS tumour, 5tumours (5th edition, 2021), many of which are molecularly defined 3.
- adult-type diffuse
astrocyticgliomas- astrocytoma, IDH-mutant: WHO CNS grade 2 to 4
-
oligodendroglioma, IDH-mutant, and 1p/19q-codeleted: WHO CNS grade 2 to 3 - glioblastoma, IDH-wildtype: WHO CNS grade 4
- paediatric-type low-grade
astrocyticgliomas- angiocentric glioma: WHO CNS grade 1
- diffuse astrocytoma, MYB- or MYBL1-altered: WHO CNS grade 1
- diffuse low-grade glioma, MAPK pathway-altered
- paediatric-type high-grade
astrocyticgliomas - circumscribed
astrocyticgliomas-
astroblastoma:
WHO CNS grade - high-grade astrocytoma with piloid features
- pilocytic astrocytoma: WHO CNS grade 1
- pilomyxoid astrocytoma: WHO CNS grade 2
- pleomorphic xanthoastrocytoma: WHO CNS grade 2
- subependymal giant cell astrocytoma: WHO CNS grade1
-
astroblastoma:
Additionally, some tumours also contain astrocytic components, and it is often this component that dictateddictates biological behaviour. Examples include:
Most of these tumours have strikingly differing demographics, imaging appearances, treatment and prognosis and thus they are, along with spinal astrocytomas discussed separately.
Note: anaplastic astrocytoma, gliomatosis cerebri, fibrillary astrocytoma and protoplasmic astrocytoma are, gemistocytic astrocytoma are no longer recognised as distinct entities in the current WHO classification of CNS tumours
-</ol><p>These can further be divided into individual entities (as described in the <a href="/articles/who-classification-of-cns-tumours-1">WHO classification of CNS tumour, 5<sup>th</sup> edition, 2021</a>) many of which are molecularly defined <sup>3</sup>. </p><ul>-<li>adult-type diffuse astrocytic gliomas <ul>- +</ol><p>These can further be divided into individual entities as described in the <a href="/articles/who-classification-of-cns-tumours-1">WHO classification of CNS tumours</a> (5<sup>th</sup> edition, 2021), many of which are molecularly defined <sup>3</sup>. </p><ul>
- +<li>adult-type diffuse gliomas <ul>
-<a href="/articles/oligodendroglioma">oligodendroglioma, IDH-mutant, and 1p/19q-codeleted</a>: WHO CNS grade 2 to 3</li>-<li>-<li>paediatric-type low-grade astrocytic gliomas<ul>- +<li>paediatric-type low-grade gliomas<ul>
-<li>paediatric-type high-grade astrocytic gliomas<ul>- +<li>paediatric-type high-grade gliomas<ul>
-<a href="/articles/diffuse-hemispheric-glioma-h3-g34-mutant">diffuse hemispheric glioma, H3 G34-mutant</a>: WHO CNS grade 4</li>-<li><a href="/articles/diffuse-pediatric-type-high-grade-glioma-h3-wildtype-and-idh-wildtype">diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype</a></li>-<li><a href="/articles/infant-type-hemispheric-glioma">infant-type hemispheric glioma</a></li>- +<a href="/articles/diffuse-hemispheric-glioma-h3-g34-mutant-1">diffuse hemispheric glioma, H3 G34-mutant</a>: WHO CNS grade 4</li>
- +<li><a href="/articles/diffuse-pediatric-type-high-grade-glioma-h3-wildtype-and-idh-wildtype">diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype</a></li>
- +<li><a href="/articles/infant-type-hemispheric-glioma-1">infant-type hemispheric glioma</a></li>
-<li>circumscribed astrocytic gliomas<ul>- +<li>circumscribed gliomas<ul>
-<a href="/articles/astroblastoma-mn1-altered">astroblastoma</a>: WHO CNS grade</li>- +<a href="/articles/astroblastoma-mn1-altered">astroblastoma</a>: </li>
-</ul><p>Additionally, some tumours also contain astrocytic components, and it is often this component that dictated biological behaviour. Examples include:</p><ul>-<li><a href="/articles/ganglioglioma">ganglioglioma</a></li>-<li><a href="/articles/polymorphous-low-grade-neuroepithelial-tumour-of-the-young">polymorphous low-grade neuroepithelial tumour of the young</a></li>-</ul><p>Most of these tumours have strikingly differing demographics, imaging appearances, treatment and prognosis and thus they are, along with <a href="/articles/spinal-astrocytoma">spinal astrocytomas</a> discussed separately.</p><p><strong>Note:</strong> <a href="/articles/anaplastic-astrocytoma-historical">anaplastic astrocytoma</a>, <a href="/articles/gliomatosis-cerebri">gliomatosis cerebri</a>, <a href="/articles/fibrillary-astrocytoma-historical">fibrillary astrocytoma</a> and <a href="/articles/protoplasmic-astrocytoma-historical">protoplasmic astrocytoma</a> are no longer recognised in the current <a href="/articles/who-classification-of-cns-tumours-1">WHO classification of CNS tumours</a></p>- +</ul><p>Additionally, some tumours also contain astrocytic components, and it is often this component that dictates biological behaviour. Examples include:</p><ul><li><a href="/articles/ganglioglioma">ganglioglioma</a></li></ul><p>Most of these tumours have strikingly differing demographics, imaging appearances, treatment and prognosis and thus they are, along with <a href="/articles/spinal-astrocytoma">spinal astrocytomas</a> discussed separately.</p><p><strong>Note:</strong> <a href="/articles/anaplastic-astrocytoma-historical">anaplastic astrocytoma</a>, <a href="/articles/gliomatosis-cerebri">gliomatosis cerebri</a>, <a href="/articles/fibrillary-astrocytoma-historical">fibrillary astrocytoma</a> and <a href="/articles/protoplasmic-astrocytoma-historical">protoplasmic astrocytoma</a>, <a href="/articles/gemistocytic-astrocytoma-historical">gemistocytic astrocytoma</a> are no longer recognised as distinct entities in the current <a href="/articles/who-classification-of-cns-tumours-1">WHO classification of CNS tumours</a></p>
Images Changes:
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Image ( destroy )
Ddx
was set to
.
Caption
was removed:
Position
was set to
.
Unable to process the form. Check for errors and try again.