Axillary lymph nodes
Updates to Article Attributes
The axillary lymph nodes, also known commonly as axillary nodes, are a group of lymph nodes in the axilla andthat receive lymph from vessels that drain the arm, the walls of the thorax, the breast and and the upper walls of the abdomen.
Gross anatomy
There are five axillary lymph node groups, namely the lateral (humeral), anterior (pectoral), posterior (subscapular), central and apical nodes. The apical nodes are the final common pathway for all of the axillary lymph nodes.
Lateral (humeral) lymph nodes
location: posteromedial to axillary vein
receives: lymph from most of the upper limb
drains into: central, apical and deep cervical nodes
Anterior (pectoral) lymph nodes
location: inferior border of pectoralis minor, near lateral thoracic vessels
receives: lymph from skin and muscles of the supraumbilical anterolateral body wall, breast
drains into: central and apical nodes
Posterior (subscapular) lymph nodes
location: along subscapular vessels on inferior margin of the posterior axillary wall
receives: lymph from skin and muscles of the posterior and inferior body wall
drains into: central and apical nodes
Central lymph nodes
location: fat of the axilla
receives: the above mentioned lateral, anterior and posterior lymph node groups
drains into: apical nodes
Apical (terminal) lymph nodes
location: posterior and superior to pectoralis minor, towards the axillary vein
receives: lymph from cephalic vein nodes,
upperupper peripheral breast, the above mentioned central nodesdrains into: subclavian trunk (may drain into jugulosubclavian venous trunk,subclavian vein,jugular lymphatic trunk,right lymphatic duct (left into thoracic duct),
inferiorinferior deep cervical nodes)
Lymphatic pathways
Lymphatics pass around the edge of the pectoralis major and and reach the pectoral group of axillary nodes. Routes Routes through or between the pectoral muscles may lead directly to the apical nodes of the axilla. Lymphatics Lymphatics follow the blood vessels through the pectoralis major and enter the parasternal (internal thoracic) nodes.
Connections may lead across the median plane and hence to the contralateral breast. Lymphatics may reach the sheath of of the rectus abdominis muscle and and the subperitoneal and subhepatic plexuses.
There is free communication between nodes below and above the clavicle and between the axillary and cervical nodes.
Surgical levels
There are three surgical levels of axillary lymph nodes which use the pectoralis minor muscle as the key landmark; this classification was developed by an American pathologist, John W Berg 7:
level I:
belowbelow the lower edge of the pectoralis minor musclelevel II: underneath/posterior
the pectoralis minor muscle-
level III: above/medialto the pectoralis minor muscle level III: above/medial to the pectoralis minor muscle
The lymphatic drainage of the breast is of great importance in the spread of carcinoma and about three-quarters of it is to the axillary nodes.
Radiographic appearance
In breast imaging, there are several schools of thought as to when to biopsy axillary nodes. Many suggest biopsying when the following features are present:
loss or disruption of central fatty hilum
loss or pericapsular fat line
parenchymal cortical thickness greater than 2.5 mm
presence of abnormal colour flow
irregular outer margins
See also
-<p>The<strong> axillary lymph nodes</strong>, also known commonly as <strong>axillary nodes</strong>, are a group of <a href="/articles/lymph-nodes">lymph nodes</a> in the <a href="/articles/axilla">axilla</a> and receive lymph from vessels that drain the arm, the walls of the thorax, the <a href="/articles/breast">breast</a> and the upper walls of the abdomen.</p><h4>Gross anatomy</h4><p>There are five axillary lymph node groups, namely the lateral (humeral), anterior (pectoral), posterior (subscapular), central and apical nodes. The apical nodes are the final common pathway for all of the axillary lymph nodes.</p><h6>Lateral (humeral) lymph nodes</h6><ul>-<li>-<strong>location:</strong> posteromedial to <a href="/articles/axillary-vein-1">axillary vein</a>-</li>-<li>-<strong>receives:</strong> lymph from most of the upper limb</li>-<li>-<strong>drains into:</strong> central, apical and deep cervical nodes</li>- +<p>The<strong> axillary lymph nodes</strong>, also known commonly as <strong>axillary nodes</strong>, are a group of <a href="/articles/lymph-nodes">lymph nodes</a> in the <a href="/articles/axilla">axilla</a> that receive <a href="/articles/lymph" title="Lymph">lymph</a> from vessels that drain the arm, the walls of the <a href="/articles/thorax-1" title="Thorax">thorax</a>, the <a href="/articles/breast">breast</a> and the upper walls of the abdomen.</p><h4>Gross anatomy</h4><p>There are five axillary lymph node groups, namely the lateral (humeral), anterior (pectoral), posterior (subscapular), central and apical nodes. The apical nodes are the final common pathway for all of the axillary lymph nodes.</p><h6>Lateral (humeral) lymph nodes</h6><ul>
- +<li><p><strong>location:</strong> posteromedial to <a href="/articles/axillary-vein-1">axillary vein</a></p></li>
- +<li><p><strong>receives:</strong> lymph from most of the upper limb</p></li>
- +<li><p><strong>drains into:</strong> central, apical and deep cervical nodes</p></li>
-<li>-<strong>location:</strong> inferior border of pectoralis minor, near lateral thoracic vessels</li>-<li>-<strong>receives:</strong> lymph from skin and muscles of the supraumbilical anterolateral body wall, breast</li>-<li>-<strong>drains into:</strong> central and apical nodes</li>- +<li><p><strong>location:</strong> inferior border of pectoralis minor, near lateral thoracic vessels</p></li>
- +<li><p><strong>receives:</strong> lymph from skin and muscles of the supraumbilical anterolateral body wall, breast</p></li>
- +<li><p><strong>drains into:</strong> central and apical nodes</p></li>
-<li>-<strong>location:</strong> along subscapular vessels on inferior margin of the posterior axillary wall</li>-<li>-<strong>receives:</strong> lymph from skin and muscles of the posterior and inferior body wall</li>-<li>-<strong>drains into:</strong> central and apical nodes</li>- +<li><p><strong>location:</strong> along subscapular vessels on inferior margin of the posterior axillary wall</p></li>
- +<li><p><strong>receives:</strong> lymph from skin and muscles of the posterior and inferior body wall</p></li>
- +<li><p><strong>drains into:</strong> central and apical nodes</p></li>
-<li>-<strong>location:</strong> fat of the axilla</li>-<li>-<strong>receives:</strong> the above mentioned lateral, anterior and posterior lymph node groups</li>-<li>-<strong>drains into:</strong> apical nodes</li>- +<li><p><strong>location:</strong> fat of the axilla</p></li>
- +<li><p><strong>receives:</strong> the above mentioned lateral, anterior and posterior lymph node groups</p></li>
- +<li><p><strong>drains into:</strong> apical nodes</p></li>
-<li>-<strong>location:</strong> posterior and superior to pectoralis minor, towards the axillary vein</li>-<li>-<strong>receives:</strong> lymph from cephalic vein nodes, upper peripheral breast, the above mentioned central nodes</li>-<li>-<strong>drains into:</strong> <a href="/articles/subclavian-trunk">subclavian trunk</a> (may drain into jugulosubclavian venous trunk, <a href="/articles/subclavian-vein">subclavian vein</a>, <a href="/articles/jugular-trunk">jugular lymphatic trunk</a>, <a href="/articles/right-lymphatic-duct">right lymphatic duct</a> (left into <a href="/articles/thoracic-duct">thoracic duct</a>), inferior deep cervical nodes)</li>-</ul><h5>Lymphatic pathways </h5><p>Lymphatics pass around the edge of the <a href="/articles/pectoralis-major-muscle-1">pectoralis major</a> and reach the pectoral group of axillary nodes. Routes through or between the pectoral muscles may lead directly to the apical nodes of the axilla. Lymphatics follow the blood vessels through the pectoralis major and enter the <a href="/articles/internal-thoracic-lymph-nodes">parasternal (internal thoracic) nodes</a>.</p><p>Connections may lead across the median plane and hence to the contralateral breast. Lymphatics may reach the <a href="/articles/rectus-sheath">sheath</a> of the <a href="/articles/rectus-abdominis-muscle">rectus abdominis muscle</a> and the subperitoneal and subhepatic plexuses. </p><p>There is free communication between nodes below and above the clavicle and between the axillary and cervical nodes.</p><h5>Surgical levels</h5><p>There are three surgical levels of axillary lymph nodes:</p><ul>-<li>-<strong>level I</strong>: below the lower edge of the <a href="/articles/pectoralis-minor-muscle-1">pectoralis minor muscle</a>-</li>-<li>-<strong>level II</strong>: underneath/posterior the pectoralis minor muscle</li>-<li>-<strong>level III</strong>: above/medial the pectoralis minor muscle</li>- +<li><p><strong>location:</strong> posterior and superior to pectoralis minor, towards the axillary vein</p></li>
- +<li><p><strong>receives:</strong> lymph from cephalic vein nodes, upper peripheral breast, the above mentioned central nodes</p></li>
- +<li><p><strong>drains into:</strong> <a href="/articles/subclavian-trunk">subclavian trunk</a> (may drain into jugulosubclavian venous trunk, <a href="/articles/subclavian-vein">subclavian vein</a>, <a href="/articles/jugular-trunk">jugular lymphatic trunk</a>, <a href="/articles/right-lymphatic-duct">right lymphatic duct</a> (left into <a href="/articles/thoracic-duct">thoracic duct</a>), inferior deep cervical nodes)</p></li>
- +</ul><h5>Lymphatic pathways </h5><p>Lymphatics pass around the edge of the <a href="/articles/pectoralis-major-muscle-1">pectoralis major</a> and reach the pectoral group of axillary nodes. Routes through or between the pectoral muscles may lead directly to the apical nodes of the axilla. Lymphatics follow the blood vessels through the pectoralis major and enter the <a href="/articles/internal-thoracic-lymph-nodes">parasternal (internal thoracic) nodes</a>.</p><p>Connections may lead across the median plane and hence to the contralateral breast. Lymphatics may reach the <a href="/articles/rectus-sheath">sheath</a> of the <a href="/articles/rectus-abdominis-muscle">rectus abdominis muscle</a> and the subperitoneal and subhepatic plexuses. </p><p>There is free communication between nodes below and above the clavicle and between the axillary and cervical nodes.</p><h5>Surgical levels</h5><p>There are three surgical levels of axillary lymph nodes which use the <a href="/articles/pectoralis-minor-muscle-1" title="Pectoralis minor muscle">pectoralis minor muscle</a> as the key landmark; this classification was developed by an American pathologist, John W Berg <sup>7</sup>:</p><ul>
- +<li><p><strong>level I</strong>: below the lower edge of the pectoralis minor muscle</p></li>
- +<li><p><strong>level II</strong>: underneath/posterior to the pectoralis minor muscle</p></li>
- +<li><p><strong>level III</strong>: above/medial to the pectoralis minor muscle</p></li>
-<li>loss or disruption of central fatty hilum</li>-<li>loss or pericapsular fat line</li>-<li>parenchymal cortical thickness greater than 2.5 mm</li>-<li>presence of abnormal colour flow</li>-<li>irregular outer margins</li>- +<li><p>loss or disruption of central fatty hilum</p></li>
- +<li><p>loss or pericapsular fat line</p></li>
- +<li><p>parenchymal cortical thickness greater than 2.5 mm</p></li>
- +<li><p>presence of abnormal colour flow</p></li>
- +<li><p>irregular outer margins</p></li>
-<li><a href="/articles/bilateral-axillary-lymphadenopathy-differential">differential diagnosis of bilateral axillary lymphadenopathy</a></li>-<li><a href="/articles/unilateral-axillary-lymphadenopathy-differential">differential diagnosis of unilateral axillary lymphadenopathy</a></li>-<li><a href="/articles/intramammary-lymph-nodes">intramammary lymph nodes</a></li>-<li><a href="/articles/interpectoral-lymph-node-1">Rotter lymph nodes</a></li>-<li><a href="/cases/normal-and-pathological-axillary-lymph-nodes">Normal and pathological axillary lymph nodes</a></li>- +<li><p><a href="/articles/bilateral-axillary-lymphadenopathy-differential">differential diagnosis of bilateral axillary lymphadenopathy</a></p></li>
- +<li><p><a href="/articles/unilateral-axillary-lymphadenopathy-differential">differential diagnosis of unilateral axillary lymphadenopathy</a></p></li>
- +<li><p><a href="/articles/intramammary-lymph-nodes">intramammary lymph nodes</a></p></li>
- +<li><p><a href="/articles/interpectoral-lymph-node-1">Rotter lymph nodes</a></p></li>
- +<li><p><a href="/cases/normal-and-pathological-axillary-lymph-nodes">normal and pathological axillary lymph nodes</a></p></li>
References changed:
- 7. Berg J. The Significance of Axillary Node Levels in the Study of Breast Carcinoma. Cancer. 1955;8(4):776-8. <a href="https://doi.org/10.1002/1097-0142(1955)8:4<776::aid-cncr2820080421>3.0.co;2-b">doi:10.1002/1097-0142(1955)8:4<776::aid-cncr2820080421>3.0.co;2-b</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/13240660">Pubmed</a>