Bilateral thalamic glioma
Updates to Article Attributes
Bilateral thalamic gliomas are rare but characteristic low-grade astrocytomas that occur in both children and young adults.
Clinical presentation
Presentation may vary with age. Young children with bilateral thalamic glioma often have signs of increased intracranial pressure and movement disorders, while older children and adults often experience mental deterioration with behavioral impairment such as personality changes or dementia.
Pathology
It is a type of low-grade astrocytoma (World Health Organizatiοn grade II).
Radiographic features
CT and MRI typically show expansion of both thalami. While often symmetric, the involvement can also be asymmetric. Tumours may spread to involve the striatum. Depending on the degree of mass-effect, there may be accompanying hydrocephalus.
MRI
- T2/FLAIR: hyperintense
- T1: isointense
- DWI: no diffusion restriction
- T1 C+ (Gd): no post-contrast enhancement
Treatment and prognosis
Because of the deep location of the lesions, prognosis is very poor despite therapy.
See also
-<p><strong>Bilateral thalamic gliomas </strong>are rare but characteristic low-grade <a href="/articles/astrocytic-tumours">astrocytomas</a> that occur in both children and young adults.</p><h4>Clinical presentation</h4><p>Presentation may vary with age. Young children with bilateral thalamic glioma often have signs of increased intracranial pressure and movement disorders, while older children and adults often experience mental deterioration with behavioral impairment such as personality changes or dementia.</p><h4>Pathology</h4><p>It is a type of <a href="/articles/astrocytoma-idh-mutant">low-grade astrocytoma</a> (World Health Organizatiοn grade II).</p><h4>Radiographic features</h4><p>CT and MRI typically show expansion of both thalami. While often symmetric, the involvement can also be asymmetric. Tumours may spread to involve the <a href="/articles/corpus-striatum">striatum</a>. Depending on the degree of mass-effect, there may be accompanying <a href="/articles/hydrocephalus">hydrocephalus</a>.</p><h5>MRI</h5><ul>- +<p><strong>Bilateral thalamic gliomas </strong>are rare but characteristic low-grade <a href="/articles/astrocytic-tumours">astrocytomas</a> that occur in both children and young adults.</p><h4>Clinical presentation</h4><p>Presentation may vary with age. Young children with bilateral thalamic glioma often have signs of increased intracranial pressure and movement disorders, while older children and adults often experience mental deterioration with behavioral impairment such as personality changes or dementia.</p><h4>Pathology</h4><p>It is a type of <a href="/articles/astrocytoma-idh-mutant-1">low-grade astrocytoma</a> (World Health Organizatiοn grade II).</p><h4>Radiographic features</h4><p>CT and MRI typically show expansion of both thalami. While often symmetric, the involvement can also be asymmetric. Tumours may spread to involve the <a href="/articles/corpus-striatum">striatum</a>. Depending on the degree of mass-effect, there may be accompanying <a href="/articles/hydrocephalus">hydrocephalus</a>.</p><h5>MRI</h5><ul>
Image 3 MRI (FLAIR) ( create )
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