Question 2252
{"accessible":false,"alternatives":[{"id":11157,"text":"is associated with improved prognosis"},{"id":11158,"text":"has elevated cerebral blood volume"},{"id":11159,"text":"has prominent enhancement"},{"id":11160,"text":"has prominent edema"},{"id":11161,"text":"most often occurs following Stupp protocol"}],"archived":false,"correctAlternativeId":11158,"explanation":"\u003cp\u003ePseudoresponse\u0026nbsp;refers to the phenomenon of tumors appearing to respond to a specific treatment (most often antiangiogenic agents, e.g. bevacizumab and cediranib) on imaging criteria when the lesion actually remains stable or has even progressed.\u003c/p\u003e\u003cp\u003eA rapid decrease in contrast enhancement and edema can be observed in a short period of time after treatment, often without any significant change in actual tumor size. This effect is largely due to reconstitution of the blood-brain barrier.\u0026nbsp;\u003c/p\u003e","id":2252,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2252","nextQuestionPath":null,"relatedArticles":[{"id":4910,"title":"Glioblastoma, IDH-wildtype","link":"/articles/glioblastoma-idh-wildtype?lang=us"},{"id":34958,"title":"Tumor pseudoresponse","link":"/articles/tumour-pseudoresponse?lang=us"},{"id":34959,"title":"Tumor pseudoprogression (brain tumors)","link":"/articles/tumour-pseudoprogression-brain-tumors?lang=us"},{"id":42300,"title":"Stupp protocol","link":"/articles/stupp-protocol?lang=us"}],"alsoUsedIn":[{"id":1169,"kind":"Course","title":"Adult Neuroradiology Review Course - page 1169","link":"https://radiopaedia.org/courses/adult-neuroradiology-review-course/pages/1169"},{"id":1169,"kind":"Course","title":"Adult Neuroradiology Review Course - page 1169","link":"https://radiopaedia.org/courses/adult-brain-mri-review-course-2015-online-video/pages/1169"},{"id":1222,"kind":"Course","title":"Diffuse Gliomas Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/diffuse-gliomas-learning-pathway/pages/1222"},{"id":1222,"kind":"Course","title":"Brain Tumours Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/brain-tumours-learning-pathway/pages/1222"}],"stem":"\u003cp\u003eWhich of the following is most often \u003cstrong\u003eTRUE\u003c/strong\u003e regarding pseudoresponse in high-grade gliomas?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/2252"}],"attemptsPercentages":[{"alternativeId":"11159","percentage":5},{"alternativeId":"11158","percentage":64},{"alternativeId":"11157","percentage":9},{"alternativeId":"11160","percentage":11},{"alternativeId":"11161","percentage":12}],"promptToLogin":false,"questionManager":false,"articleId":"blood-brain-barrier"}