BRAF
Updates to Article Attributes
Body
was changed:
BRAF (B-Raf proto-oncogene serine/threonine-protein kinase) is a proto-oncogene, encoding for a serine/threonine protein kinase. Mutations of BRAF are the most common alteration of the RAS/MAPK pathway and these have been identified in a variety of tumours and congenital syndromes including 1-5:
- tumours
- central nervous system (especially paediatric low-grade gliomas)
- colorectal carcinoma
- lung cancer (adenocarcinoma and non-small cell)
- malignant melanoma
- Ameloblastoma
- non-Hodgkin lymphoma
- thyroid carcinoma
- ovarian cancer
- congenital syndromes
Mutations
A variety of mutations are recognized, the most commonly encountered being:
- BRAF V600E point mutation (most common)
- BRAF fusion (KIAA1549:BRAF fusion)
-<p><em><strong>BRAF</strong></em> (B-Raf proto-oncogene serine/threonine-protein kinase) is a <a title="proto-oncogene" href="/articles/proto-oncogene">proto-oncogene</a>, encoding for a serine/threonine protein kinase. Mutations of <em>BRAF</em> are the most common alteration of the <a href="/articles/mapk-pathway">RAS/MAPK pathway</a> and these have been identified in a variety of tumours and congenital syndromes including <sup>1-5</sup>: </p><ul>- +<p><em><strong>BRAF</strong></em> (B-Raf proto-oncogene serine/threonine-protein kinase) is a <a href="/articles/proto-oncogene">proto-oncogene</a>, encoding for a serine/threonine protein kinase. Mutations of <em>BRAF</em> are the most common alteration of the <a href="/articles/mapk-pathway">RAS/MAPK pathway</a> and these have been identified in a variety of tumours and congenital syndromes including <sup>1-5</sup>: </p><ul>
- +<li><a title="Ameloblastoma" href="/articles/ameloblastoma">Ameloblastoma</a></li>
Unable to process the form. Check for errors and try again.