Callen MS-ADEM criteria
Disclosures
- updated 16 Jan 2024:
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
Updates to Article Attributes
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The Callen MS-ADEM criteria can be useful in differentiating between acute disseminated encephalomyelitis (ADEM) and and multiple sclerosis (MS) in in children, as the first attack of immune-mediated demyelination is a frequent diagnostic challenge.
Usage
Given the diagnostic challenge, several diagnostic criteria may be used to differentiate, e.g. Barkhof criteria, KIDMUS criteria, Callen MS-ADEM criteria, Callen diagnostic MS criteria. A 2010 study compared these different criteria, with the1 showing the best combination of sensitivity (75%specificity (95%perform better than others (e.g. Barkhof criteria, McDonald 2017, MAGMINS)2,3.
Criteria
The proposed criteria can only be applied to distinguish children with the clinical presentation of ADEM from that of a first MS attack.
At least two out of the three following criteria should be fulfilled for MS diagnosis1:
absence of a diffuse bilateral lesion pattern
presence of black holes
two periventricular lesions
-<p>The <strong>Callen MS-ADEM criteria</strong> can be useful in differentiating between <a href="/articles/acute-disseminated-encephalomyelitis-adem-1">acute disseminated encephalomyelitis (ADEM)</a> and <a href="/articles/multiple-sclerosis">multiple sclerosis (MS)</a> in children, as the first attack of immune-mediated <a href="/articles/demyelination">demyelination</a> is a frequent diagnostic challenge.</p><p>Given the diagnostic challenge, several diagnostic criteria may be used to differentiate, e.g. <a href="/articles/barkhof-criteria">Barkhof criteria</a>, <a href="/articles/kidmus-criteria">KIDMUS criteria</a>, Callen MS-ADEM criteria, <a href="/articles/callen-diagnostic-ms-criteria">Callen diagnostic MS criteria</a>. A 2010 study compared these different criteria, with the Callen MS-ADEM criteria <sup>1</sup> showing the best combination of sensitivity (75%) and specificity (95%) <sup>2</sup>.</p><h4>Criteria</h4><p>The proposed criteria can only be applied to distinguish children with the clinical presentation of ADEM from that of a first MS attack.</p><p>At least two out of the three following criteria should be fulfilled for MS diagnosis:</p><ul>-<li>absence of a diffuse bilateral lesion pattern</li>-<li>presence of <a title="T1 black holes" href="/articles/t1-black-holes-1">black holes</a>-</li>-<li>two periventricular lesions </li>- +<p>The <strong>Callen MS-ADEM criteria</strong> can be useful in differentiating between <a href="/articles/acute-disseminated-encephalomyelitis-adem-1">acute disseminated encephalomyelitis (ADEM)</a> and <a href="/articles/multiple-sclerosis">multiple sclerosis (MS)</a> in children, as the first attack of immune-mediated <a href="/articles/demyelination">demyelination</a> is a frequent diagnostic challenge.</p><h4>Usage</h4><p>The Callen MS-ADEM criteria compare well against several other diagnostic criteria (e.g. <a href="/articles/kidmus-criteria">KIDMUS criteria</a>, IPMSSG criteria) and perform better than others (e.g. <a href="/articles/barkhof-criteria">Barkhof criteria</a>, McDonald 2017, MAGMINS) <sup>2,3</sup>.</p><h4>Criteria</h4><p>The criteria can only be applied to distinguish children with the clinical presentation of ADEM from that of a first MS attack. At least two out of the three following criteria should be fulfilled for MS diagnosis <sup>1</sup>:</p><ul>
- +<li><p>absence of a diffuse bilateral lesion pattern</p></li>
- +<li><p>presence of <a href="/articles/t1-black-holes-1" title="T1 black holes">black holes</a></p></li>
- +<li><p>two periventricular lesions </p></li>
References changed:
- 1. Callen D, Shroff M, Branson H et al. Role of MRI in the Differentiation of ADEM from MS in Children. Neurology. 2009;72(11):968-73. <a href="https://doi.org/10.1212/01.wnl.0000338630.20412.45">doi:10.1212/01.wnl.0000338630.20412.45</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/19038851">Pubmed</a>
- 2. Ketelslegers I, Neuteboom R, Boon M, Catsman-Berrevoets C, Hintzen R, Hintzen R. A Comparison of MRI Criteria for Diagnosing Pediatric ADEM and MS. Neurology. 2010;74(18):1412-5. <a href="https://doi.org/10.1212/WNL.0b013e3181dc138b">doi:10.1212/WNL.0b013e3181dc138b</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/20335562">Pubmed</a>
- 3. Boesen M, Blinkenberg M, Thygesen L, Ilginiene J, Langkilde A. Magnetic Resonance Imaging Criteria at Onset to Differentiate Pediatric Multiple Sclerosis from Acute Disseminated Encephalomyelitis: A Nationwide Cohort Study. Mult Scler Relat Disord. 2022;62:103738. <a href="https://doi.org/10.1016/j.msard.2022.103738">doi:10.1016/j.msard.2022.103738</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/35452961">Pubmed</a>
- 1. D.J.A. Callen, M. M. Shroff, H. M. Branson et-al. Role of MRI in the differentiation of ADEM from MS in children. (2009) Neurology. 72 (11): 968. <a href="https://doi.org/10.1212/01.wnl.0000338630.20412.45">doi:10.1212/01.wnl.0000338630.20412.45</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/19038851">Pubmed</a> <span class="ref_v4"></span>
- 2. I.A. Ketelslegers, R.F. Neuteboom, M. Boon et-al. On behalf of the Dutch Pediatric MS Study Group. A comparison of MRI criteria for diagnosing pediatric ADEM and MS. (2010) Neurology. 74 (18): 1412. <a href="https://doi.org/10.1212/WNL.0b013e3181dc138b">doi:10.1212/WNL.0b013e3181dc138b</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/20335562">Pubmed</a> <span class="ref_v4"></span>
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Callen criteria
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