Cardiomyopathy in hemochromatosis

Last revised by David Carroll on 12 Mar 2019

Cardiomyopathy in hemochromatosis refers to an iron overload cardiomyopathy which can occur in those with the condition.

In primary hemochromatosis leading to iron overload, the cardiomyopathy has classically been categorized as an infiltrative cause of restrictive cardiomyopathy. While in those with secondary hemochromatosis may lead to a dilated cardiomyopathy with severe diastolic LV dysfunction in the early stages of the disease, before LVEF is affected 2.

Practical points

The H63D mutation (common mutation of the hemochromatosis associated gene) has been shown to be significantly increased in patients with idiopathic dilated cardiomyopathy although these patients to do not get classified as a cardiomyopathy in hemochromatosis unless there is an iron overload cardiomyopathy 3.

See also

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