Carney triad
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The Carney triad (not to be confused with the related Carney Stratakis syndrome, or the unrelated Carney complex) is a rare syndrome defined by the coexistence of three tumours:
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extra-adrenal paraganglioma (e.g. spinal paraganglioma)
- initially, only functioning extra-adrenal paragangliomas were included, but subsequent work includes non-functioning extra-adrenal paragangliomas 1
- gastric gastrointestinal stromal tumours (GIST)
- pulmonary chondroma
In most cases, only 2 of the 3 tumours are present at the time of diagnosis. It typically affects young people.
History and etymology
First described by J. Aidan Carney (an American professor of pathology) and colleagues back in 19775.
-<p>The <strong>Carney triad</strong> (not to be confused with the related <a title="Carney Stratakis syndrome" href="/articles/carney-stratakis-syndrome">Carney Stratakis syndrome</a>, or the unrelated <a href="/articles/carney-complex">Carney complex</a>) is a rare syndrome defined by the coexistence of three tumours:</p><ul>- +<p>The <strong>Carney triad</strong> (not to be confused with the related <a href="/articles/carney-stratakis-syndrome">Carney Stratakis syndrome</a>, or the unrelated <a href="/articles/carney-complex">Carney complex</a>) is a rare syndrome defined by the coexistence of three tumours:</p><ul>
-<a href="/articles/extra-adrenal-paraganglioma">extra-adrenal paraganglioma </a>(e.g. <a title="Spinal paraganglioma" href="/articles/spinal-paraganglioma">spinal paraganglioma</a>)<ul><li>initially, only functioning extra-adrenal paragangliomas were included, but subsequent work includes non-functioning extra-adrenal <a href="/articles/paraganglioma-1">paragangliomas</a> <sup>1</sup>- +<a href="/articles/extra-adrenal-paraganglioma">extra-adrenal paraganglioma </a>(e.g. <a href="/articles/spinal-paraganglioma">spinal paraganglioma</a>)<ul><li>initially, only functioning extra-adrenal paragangliomas were included, but subsequent work includes non-functioning extra-adrenal <a href="/articles/paraganglioma-1">paragangliomas</a> <sup>1</sup>
-<a href="/articles/gastrointestinal-stromal-tumour-1">gastric gastrointestinal stromal tumours</a><a title="GIST" href="/articles/gastrointestinal-stromal-tumour-1"> (GIST)</a>- +<a href="/articles/gastrointestinal-stromal-tumour-1">gastric gastrointestinal stromal tumours</a><a href="/articles/gastrointestinal-stromal-tumour-1"> (GIST)</a>
-</ul><p>In most cases, only 2 of the 3 tumours are present at the time of diagnosis. It typically affects young people.</p><h4>History and etymology</h4><p>First described by <strong>J. Aidan Carney</strong> and colleagues in 1977.</p>- +</ul><p>In most cases, only 2 of the 3 tumours are present at the time of diagnosis. It typically affects young people.</p><h4>History and etymology</h4><p>First described by <strong>J. Aidan Carney</strong> (an American professor of pathology) and colleagues back in 1977 <sup>5</sup>.</p>
References changed:
- 5. Carney JA. The Triad of Gastric Epithelioid Leiomyosarcoma, Functioning Extra-Adrenal Paraganglioma, and Pulmonary Chondroma. Cancer. 1979;43(1):374-82. <a href="https://doi.org/10.1002/1097-0142(197901)43:1<374::aid-cncr2820430152>3.0.co;2-t">doi:10.1002/1097-0142(197901)43:1<374::aid-cncr2820430152>3.0.co;2-t</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/367573">Pubmed</a>
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