Cavum septum pellucidum

Changed by Tim Luijkx, 22 Jan 2015

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The cavumCavum septum pellucidum (CSP) is a normal variant CSF space between the leaflets of the septum pellucidum. It is sometimes called the fifth ventricle

Epidemiology

A CSP is present in the normal fetus, but over 85% of them fuse by 3-6 months of age meaning that a CSP persists in ~15% of the adult population.  

Gross anatomy

The CSP commonly occurs, and is often confused with the cavum vergae, which is situated posterior to the anterior columns of the fornix. During development, these spaces obliterate postero-anteriorly - the cavum vergae followed by the cavum septum pellucidum - and it is not uncommon that both occur together. 

Boundaries
  • anterior - genu: genu of the corpus callosum
  • superior -: body of the corpus callosum
  • posterior -: anterior limb and pillars of the fornix
  • inferior -: anterior commissure and the rostrum of the corpus callosum
  • lateral -: leaflets of the septum pellucidum 1

Related pathology

It has been loosely associated with 3-5:

  • schizophrenia
  • post-traumatic stress disorder
  • chronic brain trauma

However, an absent cavum septum pellucidum inantenatal antenatal imaging is a concerning feature and is associated with significant CNS anomalies 6.

Differential diagnosis

  • -<p>The <strong>cavum septum pellucidum (CSP) </strong>is a normal variant CSF space between the leaflets of the septum pellucidum. It is sometimes called the <strong>fifth ventricle</strong>. </p><h4>Epidemiology</h4><p>A CSP is present in the normal fetus, but over 85% of them fuse by 3-6 months of age meaning that a CSP persists in ~15% of the adult population.  </p><h4>Gross anatomy</h4><p>The CSP commonly occurs, and is often confused with the <a href="/articles/cavum-vergae">cavum vergae</a>, which is situated posterior to the anterior columns of the fornix. During development, these spaces obliterate postero-anteriorly - the cavum vergae followed by the cavum septum pellucidum - and it is not uncommon that both occur together. </p><h5>Boundaries</h5><ul>
  • -<li>anterior - genu of the <a href="/articles/corpus-callosum">corpus callosum</a>
  • +<p><strong>Cavum septum pellucidum (CSP) </strong>is a normal variant CSF space between the leaflets of the septum pellucidum. It is sometimes called the <strong>fifth ventricle</strong>. </p><h4>Epidemiology</h4><p>A CSP is present in the normal fetus, but over 85% of them fuse by 3-6 months of age meaning that a CSP persists in ~15% of the adult population.  </p><h4>Gross anatomy</h4><p>The CSP commonly occurs, and is often confused with the <a href="/articles/cavum-vergae">cavum vergae</a>, which is situated posterior to the anterior columns of the fornix. During development, these spaces obliterate postero-anteriorly - the cavum vergae followed by the cavum septum pellucidum - and it is not uncommon that both occur together. </p><h5>Boundaries</h5><ul>
  • +<li>anterior: genu of the <a href="/articles/corpus-callosum">corpus callosum</a>
  • -<li>superior - body of the corpus callosum</li>
  • -<li>posterior - anterior limb and pillars of the fornix</li>
  • -<li>inferior - anterior commissure and the rostrum of the corpus callosum</li>
  • -<li>lateral - leaflets of the septum pellucidum <sup>1</sup>
  • +<li>superior: body of the corpus callosum</li>
  • +<li>posterior: anterior limb and pillars of the fornix</li>
  • +<li>inferior: anterior commissure and the rostrum of the corpus callosum</li>
  • +<li>lateral: leaflets of the septum pellucidum <sup>1</sup>
  • -</ul><p>However, an <a href="/articles/absent-cavum-septum-pellucidum">absent cavum septum pellucidum</a> in <strong>antenatal imaging</strong> is a concerning feature and is associated with significant CNS anomalies <sup>6</sup>.</p><h4>Differential diagnosis</h4><ul>
  • +</ul><p>However, an <a href="/articles/absent-cavum-septum-pellucidum">absent cavum septum pellucidum</a> in antenatal imaging is a concerning feature and is associated with significant CNS anomalies <sup>6</sup>.</p><h4>Differential diagnosis</h4><ul>

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