Chromogranin A
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Chromogranin A(CgA) is biochemical marker which can be used to aid detection of neuroendocrine tumours. It is an acidic glycoprotein that widely expressed by neuroendocrine cells.
It can be elevated with:
- pheochromocytoma
- medullary thyroid carcinoma
- enterochromaffin and pancreatic islet cell tumours
. - autoimmune chronic atrophic gastritis
- gastrinoma
- multiple endocrine neoplasia syndrome type 1
- carcinoid tumours - especially malignant gastric carcinoid tumours
Serum CgA values can also be used to trend neuroendocrine tumor burden, but caution should be exercised if the patient is being treated with somatostatin analogues, as they may depress CgA levels.
See other tumour markers here.
-<p><strong>Chromogranin A</strong> is biochemical marker which can be used to aid detection of <a href="/articles/neuroendocrine-tumours">neuroendocrine tumours</a>. It is an acidic glycoprotein that widely expressed by neuroendocrine cells.</p><p>It can be elevated with:</p><ul>- +<p><strong>Chromogranin A</strong> <strong>(CgA)</strong> is biochemical marker which can be used to aid detection of <a href="/articles/neuroendocrine-tumours">neuroendocrine tumours</a>. It is an acidic glycoprotein that widely expressed by neuroendocrine cells.</p><p>It can be elevated with:</p><ul>
-<li>enterochromaffin and pancreatic islet cell tumours.</li>- +<li>enterochromaffin and pancreatic islet cell tumours</li>
-</ul><p>See other tumour markers <a href="/articles/tumour-markers">here</a>.</p>- +</ul><p>Serum CgA values can also be used to trend neuroendocrine tumor burden, but caution should be exercised if the patient is being treated with somatostatin analogues, as they may depress CgA levels.</p><p>See other tumour markers <a href="/articles/tumour-markers">here</a>.</p>
References changed:
- 3. Reiter MJ, Costello JE, Schwope RB et-al. Review of Commonly Used Serum Tumor Markers and Their Relevance for Image Interpretation. J Comput Assist Tomogr. 2015;39 (6): 825-34. <a href="http://dx.doi.org/10.1097/RCT.0000000000000297">doi:10.1097/RCT.0000000000000297</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/26248153">Pubmed citation</a><span class="auto"></span>
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