Chronic pulmonary aspergillosis

Changed by Yuranga Weerakkody, 29 Nov 2017

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Chronic pulmonary aspergillosis (CPA) is a group of chronic aspergillosis found in non-immunocompromised patients with prior or current lung disease (e.g. chronic obstructive pulmonary disease, mycobacteriosis or conditions such as diabetes).

It can manifest as several forms¹.

chronic cavitary pulmonary aspergillosis (CCPA): considered the most common form.
chronic fibrosing pulmonary aspergillosis (CFPA): may progress to this from CCPA in untreated cases.
Aspergillus nodule
aspergilloma

Clinical presentation

Patients usually present with chronic symptoms such as prolonged and relapsing cough, dyspnoea and weight loss. Acute symptoms such as haemoptysis and bronchial or pulmonary haemorrhage may however occasionally occur ³.

-<a title="chronic cavitary pulmonary aspergillosis" href="/articles/chronic-cavitary-pulmonary-aspergillosis">chronic cavitary pulmonary aspergillosis</a> (CCPA): considered the most common form.</li>
+<a href="/articles/chronic-cavitary-pulmonary-aspergillosis">chronic cavitary pulmonary aspergillosis</a> (CCPA): considered the most common form.</li>
-<a title="chronic fibrosing pulmonary aspergillosis" href="/articles/chronic-fibrosing-pulmonary-aspergillosis">chronic fibrosing pulmonary aspergillosis</a>: may progress to this from CCPA in untreated cases.</li>
~~-<li><a title="Aspergillus nodule" href="/articles/aspergillus-nodule"><em>Aspergillus</em> nodule</a></li>~~
~~-<li><a title="Aspergilloma" href="/articles/aspergilloma">aspergilloma</a></li>~~
-</ul><h4>Clinical presentation</h4><p>Patients usually present with chronic symptoms such as prolonged and relapsing cough, dyspnoea and weight loss. Acute symptoms such as haemoptysis and bronchial or pulmonary haemorrhage may however occasionally occur <sup>3</sup>.</p><h4>See also</h4><ul><li><a title="Pulmonary aspergillosis" href="/articles/pulmonary-aspergillosis">pulmonary aspergillosis</a></li></ul>
+<a href="/articles/chronic-fibrosing-pulmonary-aspergillosis">chronic fibrosing pulmonary aspergillosis</a> (CFPA): may progress to this from CCPA in untreated cases.</li>
+<li><a href="/articles/aspergillus-nodule"><em>Aspergillus</em> nodule</a></li>
+<li><a href="/articles/aspergilloma">aspergilloma</a></li>
+</ul><h4>Clinical presentation</h4><p>Patients usually present with chronic symptoms such as prolonged and relapsing cough, dyspnoea and weight loss. Acute symptoms such as haemoptysis and bronchial or pulmonary haemorrhage may however occasionally occur <sup>3</sup>.</p><h4>See also</h4><ul><li><a href="/articles/pulmonary-aspergillosis">pulmonary aspergillosis</a></li></ul>

References changed:

1. David W. Denning, Jacques Cadranel, Catherine Beigelman-Aubry, Florence Ader, Arunaloke Chakrabarti, Stijn Blot, Andrew J. Ullmann, George Dimopoulos, Christoph Lange. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. European Respiratory Journal. <a href="https://doi.org/10.1183/13993003.00583-2015">doi:10.1183/13993003.00583-2015</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/26699723">Pubmed</a> <span class="ref_v4"></span>
2. Kosmidis C, Denning DW. The clinical spectrum of pulmonary aspergillosis. Thorax. 70 (3): 270-7. <a href="https://doi.org/10.1136/thoraxjnl-2014-206291">doi:10.1136/thoraxjnl-2014-206291</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/25354514">Pubmed</a> <span class="ref_v4"></span>
3. Schweer KE, Bangard C, Hekmat K, Cornely OA. Chronic pulmonary aspergillosis. Mycoses. 57 (5): 257-70. <a href="https://doi.org/10.1111/myc.12152">doi:10.1111/myc.12152</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/24299422">Pubmed</a> <span class="ref_v4"></span>
4. Patterson KC, Strek ME. Diagnosis and treatment of pulmonary aspergillosis syndromes. Chest. 146 (5): 1358-1368. <a href="https://doi.org/10.1378/chest.14-0917">doi:10.1378/chest.14-0917</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/25367472">Pubmed</a> <span class="ref_v4"></span>

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