Desmoplasia
Updates to Article Attributes
Desmoplastic reactionDesmoplasia (DR) desmoplasiadesmoplastic reaction) is the term used by pathologists to refer to the growth of fibrous tissue around disease, usually cancer. However in dermatopathology, desmoplasia may also be seen with benign, as well as malignant, conditions.
Pathology
Histopathology
A desmoplastic reaction is a host response, characterised by a fibrotic connective tissue. It classically occurs due to the presence of malignant cells, and was initially described in breast cancer.
Histologically desmoplasia may involve very few cells or an abundance of them. The oligocellular form comprises a very low number of spindled tumour cells, thinly dispersed (usually as single cells) in a fascicular pattern, separated by bundles of sclerotic collagen, forming an extensive extracellular matrix. Whereas, the multicellular form demonstrates a large number of cells, including fibroblasts, vascular and immune cells, with a general lack of extracellular stroma 1,2.
In the skin, there are a large number of benign pathologies in which a desmoplastic reaction is well-recognised, e.g. melanocytic naevus2.
More recently it has been observed that desmoplasia may occur in the absence of malignancy, this was first observed in the normal female breast. And research suggests that the presence of desmoplasia may predispose to the formation of malignancy 1.
History and etymology
Desmoplasia is a word derived from the Ancient Greek words, "desmos" meaning to restrain and "plasis", meaning formation 1.
-<p><strong>Desmoplastic reaction</strong> (<strong>DR</strong>) (also known as <strong>desmoplasia</strong>) is the </p>- +<p><strong>Desmoplasia</strong> (also known as a <strong>desmoplastic reaction</strong>) is the term used by pathologists to refer to the growth of fibrous tissue around disease, usually cancer. However in dermatopathology, desmoplasia may also be seen with benign, as well as malignant, conditions.</p><h4>Pathology</h4><h5>Histopathology</h5><p>A desmoplastic reaction is a host response, characterised by a fibrotic connective tissue. It classically occurs due to the presence of malignant cells, and was initially described in <a href="/articles/breast-neoplasms">breast cancer</a>.</p><p>Histologically desmoplasia may involve very few cells or an abundance of them. The oligocellular form comprises a very low number of spindled tumour cells, thinly dispersed (usually as single cells) in a fascicular pattern, separated by bundles of sclerotic collagen, forming an extensive extracellular matrix. Whereas, the multicellular form demonstrates a large number of cells, including fibroblasts, vascular and immune cells, with a general lack of extracellular stroma <sup>1,2</sup>.</p><p>In the skin, there are a large number of benign pathologies in which a desmoplastic reaction is well-recognised, e.g. <a href="/articles/melanocytic-naevus">melanocytic naevus</a> <sup>2</sup>.</p><p>More recently it has been observed that desmoplasia may occur in the absence of malignancy, this was first observed in the normal female breast. And research suggests that the presence of desmoplasia may predispose to the formation of malignancy <sup>1</sup>.</p><h4>History and etymology</h4><p>Desmoplasia is a word derived from the Ancient Greek words, "desmos" meaning to restrain and "plasis", meaning formation <sup>1</sup>.</p>
References changed:
- 1. DeClerck YA. Desmoplasia: a response or a niche?. (2012) Cancer discovery. 2 (9): 772-4. <a href="https://doi.org/10.1158/2159-8290.CD-12-0348">doi:10.1158/2159-8290.CD-12-0348</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/22969116">Pubmed</a> <span class="ref_v4"></span>
- 2. Abbas O & Mahalingam M. Desmoplasia: Not Always a Bad Thing. Histopathology. 2011;58(5):643-59. <a href="https://doi.org/10.1111/j.1365-2559.2010.03617.x">doi:10.1111/j.1365-2559.2010.03617.x</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/20718872">Pubmed</a>
Tags changed:
- cases
Sections changed:
- Pathology
Systems changed:
- Oncology
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