Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma.
Epidemiology
Associations
Diffuse large B-cell lymphoma is sometimes associated with immunodeficiency, including acquired immunodeficiency syndrome.
Pathology
Classification
In the 2016 WHO classification of lymphoid neoplasms, diffuse large B-cell lymphoma, not otherwise specified (NOS), is a type of mature B-cell neoplasm and includes two molecular subgroups indicating the cell of origin:
- germinal center B-cell type
- activated B-cell type
In addition, diffuse large B-cell lymphomas with certain molecular/cytogenetic features, previously called "double-hit" or "triple-hit" lymphomas, as well as those resembling Burkitt lymphoma are now classified together as either of the following entities 1:
- high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements
- high-grade B-cell lymphoma, not otherwise specified
There are otherwise multiple specified types of diffuse large B-cell lymphomas:
- T-cell/histiocyte-rich large B-cell lymphoma
- primary diffuse large B-cell lymphoma of the central nervous system
- primary cutaneous diffuse large B-cell lymphoma, leg type
- Epstein-Barr virus-positive diffuse large B-cell lymphoma, not otherwise specified
- diffuse large B-cell lymphoma associated with chronic inflammation
- human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified (provisional entity)
Staging
See the article on lymphoma staging.