Question 688
{"accessible":false,"alternatives":[{"id":3459,"text":"they are most commonly found in the thalamus"},{"id":3460,"text":"they generally have a favorable prognosis "},{"id":3461,"text":"they range in grade from WHO grade 2 to WHO grade 4"},{"id":3462,"text":"when in the pons they are usually encountered in young adults"},{"id":3463,"text":"when in the spinal cord they are usually encountered in young adults"}],"archived":false,"correctAlternativeId":3463,"explanation":"\u003cp\u003eDiffuse midline glioma, H3 K27-altered is a specific entity added to the 2016 update of the WHO classification of CNS tumors, that represents the majority of diffuse intrinsic pontine gliomas, although identical tumors are also found elsewhere in the midline (e.g. brainstem, spinal cord and thalamus). They are aggressive tumors with a poor prognosis and are considered WHO grade 4 tumors regardless of histological features.\u003c/p\u003e\u003cp\u003eThe majority of these tumors are found in young children and are located in the pons. They are also seen elsewhere in the midline. In such cases, they tend to be encountered in children and young adults. This is particularly the case with spinal cord tumors that are seen primarily in young adults. \u0026nbsp;\u003c/p\u003e","id":688,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2590","nextQuestionPath":null,"relatedArticles":[{"id":5736,"title":"Brainstem glioma","link":"/articles/brainstem-glioma?lang=us"},{"id":6450,"title":"Pediatric posterior fossa tumors (mnemonic)","link":"/articles/paediatric-posterior-fossa-tumours-mnemonic?lang=us"},{"id":6491,"title":"Diffuse brainstem glioma (historical)","link":"/articles/diffuse-brainstem-glioma-historical?lang=us"}],"alsoUsedIn":[{"id":1222,"kind":"Course","title":"Diffuse Gliomas Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/diffuse-gliomas-learning-pathway/pages/1222"},{"id":1222,"kind":"Course","title":"Brain Tumours Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/brain-tumours-learning-pathway/pages/1222"}],"stem":"\u003cp\u003eWhich of the following is \u003cstrong\u003eTRUE\u003c/strong\u003e regarding H3 K27-altered\u0026nbsp;diffuse midline gliomas?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/688"}],"attemptsPercentages":[{"alternativeId":"3460","percentage":3},{"alternativeId":"3461","percentage":16},{"alternativeId":"3462","percentage":40},{"alternativeId":"3463","percentage":33},{"alternativeId":"3459","percentage":8}],"promptToLogin":false,"questionManager":false,"articleId":"diffuse-midline-glioma-h3-k27-altered"}