Emphysematous cholecystitis
Updates to Article Attributes
Emphysematous cholecystitis is a rare form of acute cholecystitis. It is a surgically emergent condition, due to a risk of gallbladder gangrene and perforation.
Epidemiology
Men are affected twice as commonly as women (reverse is true in most cases of acute cholecystitis).
The majority of patients are between 50 and 70 years of age and have underlying diabetes mellitus peripheral atherosclerotic disease.
Clinical presentation
Clinical manifestation is often insidious and may then progress rapidly. Up to one-thirdof-third of patients may be afebrile and localised tenderness is often not a dominant clinical feature.
Pathology
Commonly isolated organisms include Clostridium welchii/perfingrens, Escherichia coli and Bacteroides fragilis 1,12.
Vascular compromise of the cystic artery is thought to play a significant role in causing emphysematous cholecystitis. It is associated with acalculous cholecystitis (present in ~50% of cases 9-11) and carries a higher incidence of gallbladder perforation.
Radiographic features
On imaging, the condition is diagnosed when there is radiographic demonstration of air in the gall bladdergallbladder wall +/- tissues adjacent to the gallbladder +/- biliary biliary ducts, in the absence of an abnormal communication with the gastrointestinal tract 2.
Ultrasound
Ultrasonography may demonstrate highly echogenic reflectors with low-level posterior shadowing and reverberation artifact ("dirty" shadowing and "ring-down" artifact) 7.
A less common but more specific finding is small, non-shadowing echogenic foci rising up from the dependent portions of the gallbladder lumen, similar to effervescing bubbles in a glass of champagne (champagne sign).
CT
CT is considered the most sensitive and specific imaging modality for identifying gas within the gallbladder lumen or wall 4. The presence of a pneumoperitoneum indicates perforation.
Nuclear medicine
Hepatobiliary nuclear imaging may demonstrate non-visualisation of the gallbladder, along with a region of increased hepatic activity adjacent to the gallbladder fossa. This feature is sometimes termed the rim sign 10.
Treatment and prognosis
Treatment is emergent surgical intervention. Overall mortality rate is ~20% (range 15-25%), compared with less than 4% in uncomplicated cases of acute cholecystitis. Percutaneous cholecystostomy tube placement may be an option for patients who are too unwell for surgery 13.
History and etymology
It was initially described by C F Hegner in 1931 5.
Practical points
- if in doubt of the diagnosis on ultrasound, obtain an abdominal radiograph or CT to confirm the diagnosis
-<p><strong>Emphysematous cholecystitis</strong> is a rare form of <a href="/articles/acute-cholecystitis">acute cholecystitis</a>. </p><h4>Epidemiology</h4><p>Men are affected twice as commonly as women (reverse is true in most cases of acute cholecystitis).</p><p>The majority of patients are between 50 and 70 years of age and have underlying diabetes mellitus peripheral atherosclerotic disease. </p><h4>Clinical presentation</h4><p>Clinical manifestation is often insidious and may then progress rapidly. Up to one-thirdof patients may be afebrile and localised tenderness is often not a dominant clinical feature.</p><h4>Pathology</h4><p>Commonly isolated organisms include <em><a href="/articles/clostridium-welchii">Clostridium welchii</a></em>/<em>perfingrens</em>, <em><a href="/articles/escherichia-coli">Escherichia coli</a> </em>and <em><a href="/articles/bacteroides-fragilis">Bacteroides fragilis</a> <sup>1,12</sup></em>.</p><p>Vascular compromise of the <a href="/articles/cystic-artery">cystic artery</a> is thought to play a significant role in causing emphysematous cholecystitis. It is associated with <a href="/articles/acalculous-cholecystitis">acalculous cholecystitis</a> (present in ~50% of cases <sup>9-11</sup>) and carries a higher incidence of <a href="/articles/gallbladder-perforation">gallbladder perforation</a>.</p><h4>Radiographic features</h4><p><span style="font-size:13px; line-height:1.6em">On imaging the condition is diagnosed when there is radiographic demonstration of air in the gall bladder wall +/- tissues adjacent to the gallbladder +/- biliary ducts in the absence of an abnormal communication with the gastrointestinal tract </span><sup style="line-height:1.6em">2</sup><span style="font-size:13px; line-height:1.6em">.</span></p><h5>Ultrasound</h5><p>Ultrasonography may demonstrate highly echogenic reflectors with low-level posterior shadowing and reverberation artifact ("dirty" shadowing) <sup>7</sup>.</p><p>A less common but more specific finding is small, non-shadowing echogenic foci rising up from the dependent portions of the gallbladder lumen, similar to effervescing bubbles in a glass of champagne (<a title="champagne sign" href="/articles/champagne-sign">champagne sign</a>).</p><h5>CT</h5><p>CT is considered the most sensitive and specific imaging modality for identifying gas within the gallbladder lumen or wall <sup>4</sup>. The presence of a <a href="/articles/pneumoperitoneum">pneumoperitoneum</a> indicates perforation.</p><h5>Nuclear medicine</h5><p>Hepatobiliary nuclear imaging may demonstrate non-visualisation of the gallbladder, along with a region of increased hepatic activity adjacent to the gallbladder fossa. This feature is sometimes termed the rim sign <sup>10</sup>. </p><h4>Treatment and prognosis</h4><p>Treatment is emergent surgical intervention. Overall mortality rate is ~20% (range 15-25%), compared with less than 4% in uncomplicated cases of acute cholecystitis. <a title="Percutaneous cholecystostomy" href="/articles/percutaneous-cholecystostomy">Percutaneous cholecystostomy</a> tube placement may be an option for patients who are too unwell for surgery <sup>13</sup>.</p><h4>History and etymology</h4><p>It was initially described by <strong>C F Hegner</strong> in 1931 <sup>5</sup>.</p>- +<p><strong>Emphysematous cholecystitis</strong> is a rare form of <a href="/articles/acute-cholecystitis">acute cholecystitis</a>. It is a surgically emergent condition, due to a risk of gallbladder gangrene and perforation.</p><h4>Epidemiology</h4><p>Men are affected twice as commonly as women (reverse is true in most cases of acute cholecystitis).</p><p>The majority of patients are between 50 and 70 years of age and have underlying diabetes mellitus. </p><h4>Clinical presentation</h4><p>Clinical manifestation is often insidious and may then progress rapidly. Up to one-third of patients may be afebrile and localised tenderness is often not a dominant clinical feature.</p><h4>Pathology</h4><p>Commonly isolated organisms include <em><a href="/articles/clostridium-welchii">Clostridium welchii</a></em>/<em>perfingrens</em>, <em><a href="/articles/escherichia-coli">Escherichia coli</a> </em>and <em><a href="/articles/bacteroides-fragilis">Bacteroides fragilis</a> <sup>1,12</sup></em>.</p><p>Vascular compromise of the <a href="/articles/cystic-artery">cystic artery</a> is thought to play a significant role in causing emphysematous cholecystitis. It is associated with <a href="/articles/acalculous-cholecystitis">acalculous cholecystitis</a> (present in ~50% of cases <sup>9-11</sup>) and carries a higher incidence of <a href="/articles/gallbladder-perforation">gallbladder perforation</a>.</p><h4>Radiographic features</h4><p>On imaging, the condition is diagnosed when there is radiographic demonstration of air in the gallbladder wall +/- biliary ducts, in the absence of an abnormal communication with the gastrointestinal tract <sup>2</sup>.</p><h5>Ultrasound</h5><p>Ultrasonography may demonstrate highly echogenic reflectors with low-level posterior shadowing and reverberation artifact ("dirty" shadowing and "ring-down" artifact) <sup>7</sup>.</p><p>A less common but more specific finding is small, non-shadowing echogenic foci rising up from the dependent portions of the gallbladder lumen, similar to effervescing bubbles in a glass of champagne (<a href="/articles/champagne-sign">champagne sign</a>).</p><h5>CT</h5><p>CT is considered the most sensitive and specific imaging modality for identifying gas within the gallbladder lumen or wall <sup>4</sup>. The presence of a <a href="/articles/pneumoperitoneum">pneumoperitoneum</a> indicates perforation.</p><h5>Nuclear medicine</h5><p>Hepatobiliary nuclear imaging may demonstrate non-visualisation of the gallbladder, along with a region of increased hepatic activity adjacent to the gallbladder fossa. This feature is sometimes termed the rim sign <sup>10</sup>. </p><h4>Treatment and prognosis</h4><p>Treatment is emergent surgical intervention. Overall mortality rate is ~20% (range 15-25%), compared with less than 4% in uncomplicated cases of acute cholecystitis. <a href="/articles/percutaneous-cholecystostomy">Percutaneous cholecystostomy</a> tube placement may be an option for patients who are too unwell for surgery <sup>13</sup>.</p><h4>History and etymology</h4><p>It was initially described by <strong>C F Hegner</strong> in 1931 <sup>5</sup>.</p><h4>Practical points</h4><ul><li>if in doubt of the diagnosis on ultrasound, obtain an abdominal radiograph or CT to confirm the diagnosis</li></ul>
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- gallbladder
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