Essential thrombocythemia
Updates to Synonym Attributes
Updates to Article Attributes
Essential thrombocythaemia (ET) refers to an acquired is a myeloproliferative neoplastic stateneoplasm characterised by an expansion of the megakaryocytic lineage, leading to an isolated elevation of platelets. It falls under the group of myeloproliferative disorders.
Pathology
The disease has traditionally been a diagnosis of exclusion, requiring the absence of reactive conditions and other clonal disorders that may present with thrombocytosis. The discovery of mutations in JAK2 and MPL now allows for the positive identification of ET in more than one-half of all cases.
Diagnosis
Diagnosis is often when there is an "unexplained and persistent thrombocytosis" (platelet count > 450 × 109/L). Several diagnostic criteria have been put forward, e.g. WHO 2008 and BCSH 2010 2.
Radiographic features
Can be variable depending on the organ involved and usually suspected when there are thrombosis of various vessels or ischemic events such as recurrent strokes.
See also
-<p><strong>Essential thrombocythaemia (ET)</strong> refers to an acquired myeloproliferative neoplastic state characterised by an expansion of the megakaryocytic lineage, leading to an isolated elevation of platelets. It falls under the group of <a href="/articles/myeloproliferative-disorder">myeloproliferative disorders</a><strong>. </strong>It increases the risk of both thrombosis and haemorrhage. </p><h4>Pathology</h4><p>The disease has traditionally been a diagnosis of exclusion, requiring the absence of reactive conditions and other clonal disorders that may present with thrombocytosis. The discovery of mutations in <em>JAK2</em> and <em>MPL</em> now allows for the positive identification of ET in more than one-half of all cases. </p><h5>Diagnosis</h5><p>Diagnosis is often when there is an "unexplained and persistent thrombocytosis" (platelet count > 450 × 10<sup>9</sup>/L). Several diagnostic criteria have been put forward, e.g. WHO 2008 and BCSH 2010 <sup>2</sup>.</p><h4>Radiographic features</h4><p>Can be variable depending on the organ involved and usually suspected when there are thrombosis of various vessels or ischemic events such as recurrent strokes.</p>- +<p><strong>Essential thrombocythaemia (ET)</strong> is a <a title="Myeloproliferative neoplasm" href="/articles/myeloproliferative-neoplasm-1">myeloproliferative neoplasm</a> characterised by an expansion of the megakaryocytic lineage, leading to an isolated elevation of platelets. It increases the risk of both thrombosis and haemorrhage. </p><h4>Pathology</h4><p>The disease has traditionally been a diagnosis of exclusion, requiring the absence of reactive conditions and other clonal disorders that may present with thrombocytosis. The discovery of mutations in <em>JAK2</em> and <em>MPL</em> now allows for the positive identification of ET in more than one-half of all cases. </p><h5>Diagnosis</h5><p>Diagnosis is often when there is an "unexplained and persistent thrombocytosis" (platelet count > 450 × 10<sup>9</sup>/L). Several diagnostic criteria have been put forward, e.g. WHO 2008 and BCSH 2010 <sup>2</sup>.</p><h4>Radiographic features</h4><p>Can be variable depending on the organ involved and usually suspected when there are thrombosis of various vessels or ischemic events such as recurrent strokes.</p><h4>See also</h4><ul><li><a title="WHO classification of tumours of haematopoietic and lymphoid tissues" href="/articles/who-classification-of-tumours-of-haematopoietic-and-lymphoid-tissues-1">WHO classification of tumours of haematopoietic and lymphoid tissues</a></li></ul>
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