Fibrous meningioma
Updates to Article Attributes
Fibrous meningiomas (also known as fibroblastic meningiomas) are the second most common histological subtype of meningioma, found in 47% of all meningiomas, usually along with meningothelial histology (40%) or in isolation (7%) 1. They are, for some reason, the most common histology of intraventricular meningiomas 3.
Their epidemiology, clinical presentation, radiographic features, treatment, prognosis, and differential diagnosis are therefore discussed in the main article (see meningioma), and are not repeated here.
Pathology
Fibrous meningiomas are characterised by spindle shaped tumour cells, with narrow rod-shaped nuclei. These cells are embedded in abundant collagenous or reticulum background. Whorls are far less common than in meningothelial meningiomas, and psammoma bodies are only occasionally encountered 2-3.
Radiographic features
Although generally they have very similar appearances to meningothelial meningiomas (most commonly they are mixed in, and known as transitional meningioma), in very collagenous tumours, fibrous meningiomas can have lower T2 signal.
Differential diagnosis
The differential diagnosis is included in the general meningioma article. It should be noted that in very fibrous tumours, which have lower T2 signal, the differential specifically includes:
-<p><strong>Fibrous meningiomas </strong>(also known as <strong>fibroblastic meningiomas</strong>) are the second most common histological subtype of <a title="Meningioma" href="/articles/meningioma">meningioma</a>, found in 47% of all meningiomas, usually along with <a title="Meningothelial meningioma" href="/articles/meningothelial-meningioma">meningothelial histology</a> (40%) or in isolation (7%) <sup>1</sup>. They are, for some reason, the most common histology of <a title="Intraventricular meningiomas" href="/articles/intraventricular-meningioma">intraventricular meningiomas</a> <sup>3</sup>. </p><p>Their epidemiology, clinical presentation, radiographic features, treatment, prognosis, and differential diagnosis are therefore discussed in the main article (see <a href="/articles/meningioma">meningioma</a>), and are not repeated here. </p><h4>Pathology</h4><p>Fibrous meningiomas are characterised by spindle shaped tumour cells, with narrow rod-shaped nuclei. These cells are embedded in abundant collagenous or reticulum background. Whorls are far less common than in <a title="Meningothelial meningioma" href="/articles/meningothelial-meningioma">meningothelial meningiomas</a>, and <a title="Psammoma bodies" href="/articles/psammoma-bodies">psammoma bodies</a> are only occasionally encountered <sup>2-3</sup>. </p>- +<p><strong>Fibrous meningiomas </strong>(also known as <strong>fibroblastic meningiomas</strong>) are the second most common histological subtype of <a href="/articles/meningioma">meningioma</a>, found in 47% of all meningiomas, usually along with <a href="/articles/meningothelial-meningioma">meningothelial histology</a> (40%) or in isolation (7%) <sup>1</sup>. They are, for some reason, the most common histology of <a href="/articles/intraventricular-meningioma">intraventricular meningiomas</a> <sup>3</sup>. </p><p>Their epidemiology, clinical presentation, treatment, prognosis, and differential diagnosis are therefore discussed in the main article (see <a href="/articles/meningioma">meningioma</a>), and are not repeated here. </p><h4>Pathology</h4><p>Fibrous meningiomas are characterised by spindle shaped tumour cells, with narrow rod-shaped nuclei. These cells are embedded in abundant collagenous or reticulum background. Whorls are far less common than in <a href="/articles/meningothelial-meningioma">meningothelial meningiomas</a>, and <a href="/articles/psammoma-bodies">psammoma bodies</a> are only occasionally encountered <sup>2-3</sup>. </p><h4>Radiographic features</h4><p>Although generally they have very similar appearances to <a title="Meningothelial meningioma" href="/articles/meningothelial-meningioma">meningothelial meningiomas</a> (most commonly they are mixed in, and known as transitional meningioma), in very collagenous tumours, fibrous meningiomas can have lower T2 signal. </p><h4>Differential diagnosis</h4><p>The differential diagnosis is included in the general meningioma article. It should be noted that in very fibrous tumours, which have lower T2 signal, the differential specifically includes: </p><ul>
- +<li><a title="Solitary fibrous tumour of the dura" href="/articles/solitary-fibrous-tumour-of-the-dura">solitary fibrous tumours of the dura</a></li>
- +<li><a title="Erdheim-Chester disease" href="/articles/erdheim-chester-disease">Erdheim Chester disease</a></li>
- +</ul>
References changed:
- 1. Backer-Grøndahl T, Moen BH, Torp SH. The histopathological spectrum of human meningiomas. Int J Clin Exp Pathol. 2012;5 (3): 231-42. <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341686">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/22558478">Pubmed citation</a><span class="auto"></span>
- 2. Cancer Grading Manual. Springer. (2007) ISBN:0387337512. <a href="http://books.google.com/books?vid=ISBN0387337512">Read it at Google Books</a> - <a href="http://www.amazon.com/gp/product/0387337512">Find it at Amazon</a><span class="auto"></span>
- 3. Lee JH. Meningiomas. Springer. (2008) ISBN:1846287847. <a href="http://books.google.com/books?vid=ISBN1846287847">Read it at Google Books</a> - <a href="http://www.amazon.com/gp/product/1846287847">Find it at Amazon</a><span class="auto"></span>
Systems changed:
- Central Nervous System
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