Flat epithelial atypia
Updates to Article Attributes
Flat epithelial atypia FEAis an entity whichthat comprises any columnar cell lesion CCL with with low-grade cytologic atypia. Characterized by enlarged terminal ductal lobular units (TDLU) with with dilated acini. Consisting of one or more layers of cuboidal or columnar epithelial cells with cytologic atypia and monomorphic round to oval nuclei 1,2.
Terminology
FEAFlat epithelial atypia is a term introduced in the 3rd edition of WHO Classification of Breast Tumors in 2003, to substitute terms such as clinging carcinoma monomorphous type, atypical cystic lobules, atypical lobules type A, atypical columnar change and ductal intraepithelial neoplasia 1A 1.
Radiographic features
Amorphous and fine pleomorphic microcalcifications.
Treatment and prognosis
FEAFlat epithelial atypia can coexist with other lesions such as Atypical ductal hyperplasia, ductal-carcinoma-in-situ, and tubular carcinoma. Due to its atypical cytologic and immunophenotypic features, it may represent either a precursor to or the earliest morphologic manifestation of low-grade DCISductal-carcinoma-in-situ, as well as a precursor to invasive carcinoma (low grade), more frequently tubular carcinoma. Therefore, the differentiation of FEAflat epithelial atypia from other columnar cell lesions is clinically relevant and the identification of FEA at core biopsy should prompt excision of the remaining portion of the lesion 2.
-<p><strong>Flat epithelial atypia FEA</strong> entity which comprises any <a href="/articles/columnar-cell-lesions-breast">columnar cell lesion</a> CCL with low-grade cytologic atypia. Characterized by enlarged <a title="terminal ductal lobular units (TDLU)" href="/articles/terminal-ductal-lobular-unit">terminal ductal lobular units (TDLU)</a> with dilated acini. Consisting of one or more layers of cuboidal or columnar epithelial cells with cytologic atypia and monomorphic round to oval nuclei <sup>1,2</sup>.</p><h4>Terminology</h4><p>FEA is a term introduced in the 3rd edition of WHO Classification of Breast Tumors in 2003, to substitute terms such as clinging carcinoma monomorphous type, atypical cystic lobules, atypical lobules type A, atypical columnar change and ductal intraepithelial neoplasia 1A <sup>1</sup>.</p><h4>Radiographic features</h4><p>Amorphous and fine pleomorphic <a href="/articles/grouped-calcifications">microcalcifications</a>.</p><h4>Treatment and prognosis</h4><p>FEA can coexist with other lesions such as <a href="/articles/atypical-ductal-hyperplasia">Atypical ductal hyperplasia</a>, <a href="/articles/ductal-carcinoma-in-situ">DCIS</a>, and <a href="/articles/tubular-carcinoma-of-the-breast">tubular carcinoma</a>. Due to its atypical cytologic and immunophenotypic features, it may represent either a precursor to or the earliest morphologic manifestation of low-grade DCIS, as well as a precursor to invasive carcinoma (low grade), more frequently tubular carcinoma. Therefore, the differentiation of FEA from other columnar cell lesions is clinically relevant and the identification of FEA at core biopsy should prompt excision of the remaining portion of the lesion <sup>2</sup>.</p><p> </p>- +<p><strong>Flat epithelial atypia </strong>is an entity that comprises any <a href="/articles/columnar-cell-lesions-breast">columnar cell lesion</a> with low-grade cytologic atypia. Characterized by enlarged <a href="/articles/terminal-ductal-lobular-unit">terminal ductal lobular units</a> with dilated acini. Consisting of one or more layers of cuboidal or columnar epithelial cells with cytologic atypia and monomorphic round to oval nuclei <sup>1,2</sup>.</p><h4>Terminology</h4><p>Flat epithelial atypia is a term introduced in the 3rd edition of WHO Classification of Breast Tumors in 2003, to substitute terms such as clinging carcinoma monomorphous type, atypical cystic lobules, atypical lobules type A, atypical columnar change and ductal intraepithelial neoplasia 1A <sup>1</sup>.</p><h4>Radiographic features</h4><p>Amorphous and fine pleomorphic <a href="/articles/grouped-calcifications">microcalcifications</a>.</p><h4>Treatment and prognosis</h4><p>Flat epithelial atypia can coexist with other lesions such as <a href="/articles/atypical-ductal-hyperplasia">Atypical ductal hyperplasia</a>, <a title="DCIS" href="/articles/ductal-carcinoma-in-situ">ductal-carcinoma-in-situ</a>, and <a href="/articles/tubular-carcinoma-of-the-breast">tubular carcinoma</a>. Due to its atypical cytologic and immunophenotypic features, it may represent either a precursor to or the earliest morphologic manifestation of low-grade ductal-carcinoma-in-situ, as well as a precursor to invasive carcinoma (low grade), more frequently tubular carcinoma. Therefore, the differentiation of flat epithelial atypia from other columnar cell lesions is clinically relevant and the identification of FEA at core biopsy should prompt excision of the remaining portion of the lesion <sup>2</sup>.</p>
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