Gadobutrol

Changed by Matt A. Morgan, 28 Oct 2014

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Gadobutrol (also known as Gadovist/Gadavist^TM) is an extracellular intravenous contrast agent used in magnetic resonance imaging.

As an extracellular contrast agent, gadobutrol can be useful in a wide range of MRI imaging applications, including (but not limited to): hepatic imaging, pelvic imaging, cardiac imaging, brain and spine imaging, and musculoskeletal imaging.

Gadobutrol is a cyclic, nonionic gadolinium chelate with recommended dosage of 0.1 mmol/kg. It is completely renally excreted, with no hepatic excretion.

Of note, gadobutrol's standard concentration (1 mmol/ml) is 2x - 4x that of other commercially available gadolinium chelates, and the smaller injection volume should be considered when planning the timing of the arterial phase in postcontrast dynamic sequences.

MR contrast agents
- paramagnetic contrast agents
  - gadoversetemide (OptiMARK^TM)
  - gadoteridol (Prohance^TM)
  - gadodiamide (Ominscan^TM)
  - gadoterate meglumine (Dotarem^TM)
  - gadopenetate dimeglumine (Magnevist^TM)
  - gadobenate dimeglumine (MultiHance^TM)
  - gadobutrol (Gadavist^TM/Gadovist^TM)
  - gadoxeate disodium (Eovist ^TM )
  - gadofosveset trisodium (Ablavar ^TM )

~~-<li>gadoversetemide (OptiMARK)</li>~~
~~-<li>gadoteridol (Prohance)</li>~~
~~-<li>gadodiamide (Ominscan)</li>~~
~~-<li>gadoterate meglumine (Dotarem)</li>~~
~~-<li>gadopenetate dimeglumine (Magnevist)</li>~~
~~-<li>gadobenate dimeglumine (MultiHance)</li>~~
~~-<li>gadobutrol (Gadavist)</li>~~
~~-<li><a title="Eovist" href="/articles/gadoxetic-acid">gadoxeate disodium (Eovist)</a></li>~~
~~-<li><a title="Ablavar" href="/articles/gadofosveset">gadofosveset trisodium (Ablavar)</a></li>~~
+<li>gadoversetemide (OptiMARKTM)</li>
+<li>gadoteridol (ProhanceTM)</li>
+<li>gadodiamide (OminscanTM)</li>
+<li>gadoterate meglumine (DotaremTM)</li>
+<li>gadopenetate dimeglumine (MagnevistTM)</li>
+<li>gadobenate dimeglumine (MultiHanceTM)</li>
+<li><a title="Gadobutrol" href="/articles/gadobutrol">gadobutrol (GadavistTM/GadovistTM)</a></li>
+<li>
+<a href="/articles/gadoxetic-acid">gadoxeate disodium (Eovist</a><a title="Eovist" href="/articles/gadoxetic-acid">TM</a><a href="/articles/gadoxetic-acid">)</a>
+</li>
+<li>
+<a href="/articles/gadofosveset">gadofosveset trisodium (Ablavar</a><a title="Ablavar" href="/articles/gadofosveset">TM</a><a href="/articles/gadofosveset">)</a>
+</li>

References changed:

1. Guglielmo F, Mitchell D, Gupta S. Gadolinium Contrast Agent Selection and Optimal Use for Body MR Imaging. Radiol Clin North Am. 2014;52(4):637-56. <a href="https://doi.org/10.1016/j.rcl.2014.02.004">doi:10.1016/j.rcl.2014.02.004</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/24889165">Pubmed</a>

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