Gangliocytoma
Updates to Article Attributes
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was changed:
A gangliocytoma is related to a ganglioglioma. However, it only contains neural ganglion cells. It is a benign (WHO grade I) tumour.
Epidemiology
They account for 0.1-0.5% of all brain tumours and occur in children and young adults 2.
Pathology
The key feature is a lack of glial cells. The tumour is composed of abnormal mature ganglion cells.
Markers
Lack immunoreactivity to glial fibrillary acidic protein (GFAP).
Associations
Frequently associated with a dysplastic and malformed brain to varying degrees.
Location
Occurs most frequently at the floor of the 3rd ventricle followed by the temporal lobe, cerebellum, parieto-occipital region, frontal lobe, and spinal cord
Radiographic features
CT
Typically appears hyperattenuating on non contrast imaging.
Has little associated mass effect and minimal or no surrounding vasogenic oedema. Calcification and cyst formation can occur.
MRI
-
T1:
s olidsolid components typically hypointense - T2: solid components are typically mildly hypointense 2 ; cystic areas are hyperintense ; calcification if present can be hypointense
- T1 C+ (GAD): solid components enhance
Treatment and prognosis
They tend to grow slowly and do not undergo anaplastic change.
Differential diagnosis
See also
-<p>A <strong>gangliocytoma</strong> is related to a <a href="/articles/ganglioglioma">ganglioglioma</a>. However, it only contains neural ganglion cells. It is a benign (<a href="/articles/cns-tumours-classification-who">WHO grade I</a>) tumour. </p><h4>Epidemiology</h4><p>They account for 0.1-0.5% of all brain tumours and occur in children and young adults <sup>2</sup>.</p><h4>Pathology</h4><p>The key feature is a lack of glial cells. The tumour is composed of abnormal mature ganglion cells. </p><h5>Markers</h5><p>Lack immunoreactivity to glial fibrillary acidic protein (GFAP).</p><h5>Associations</h5><p>Frequently associated with a dysplastic and malformed brain to varying degrees.</p><h5>Location</h5><p>Occurs most frequently at the floor of the 3<sup>rd</sup> ventricle followed by the temporal lobe, cerebellum, parieto-occipital region, frontal lobe, and spinal cord</p><h4>Radiographic features</h4><h5>CT</h5><p>Typically appears hyperattenuating on non contrast imaging. </p><p>Has little associated mass effect and minimal or no surrounding vasogenic oedema. Calcification and cyst formation can occur.</p><h5>MRI </h5><ul>- +<p>A <strong>gangliocytoma</strong> is related to a <a href="/articles/ganglioglioma">ganglioglioma</a>. However, it only contains neural ganglion cells. It is a benign (<a href="/articles/cns-tumours-classification-and-grading-who">WHO grade I</a>) tumour. </p><h4>Epidemiology</h4><p>They account for 0.1-0.5% of all brain tumours and occur in children and young adults <sup>2</sup>.</p><h4>Pathology</h4><p>The key feature is a lack of glial cells. The tumour is composed of abnormal mature ganglion cells. </p><h5>Markers</h5><p>Lack immunoreactivity to glial fibrillary acidic protein (GFAP).</p><h5>Associations</h5><p>Frequently associated with a dysplastic and malformed brain to varying degrees.</p><h5>Location</h5><p>Occurs most frequently at the floor of the 3<sup>rd</sup> ventricle followed by the temporal lobe, cerebellum, parieto-occipital region, frontal lobe, and spinal cord</p><h4>Radiographic features</h4><h5>CT</h5><p>Typically appears hyperattenuating on non contrast imaging. </p><p>Has little associated mass effect and minimal or no surrounding vasogenic oedema. Calcification and cyst formation can occur.</p><h5>MRI </h5><ul>
-<strong>T1:</strong>s olid components typically hypointense </li>- +<strong>T1: </strong>solid components typically hypointense </li>
-</ul><h4>Treatment and prognosis</h4><p>They tend to grow slowly and do not undergo anaplastic change.</p><h4>See also </h4><ul><li><a href="/articles/lhermitte-duclos-disease">dysplastic cerebellar gangliocytoma</a></li></ul>- +</ul><h4>Treatment and prognosis</h4><p>They tend to grow slowly and do not undergo anaplastic change.</p><h4>Differential diagnosis</h4><ul>
- +<li><a title="Ganglioglioma" href="/articles/ganglioglioma">ganglioglioma</a></li>
- +<li><a title="Focal cortical dysplasia of Taylor" href="/articles/taylor-dysplasia">cortical dysplasia</a></li>
- +</ul><h4>See also </h4><ul><li><a href="/articles/lhermitte-duclos-disease">dysplastic cerebellar gangliocytoma</a></li></ul>
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