Gene expression classifier
Updates to Synonym Attributes
Updates to Article Attributes
Agene expression classifier (GEC) test is is a developing technology in the pathologic pathologic analysis of thyroid nodules, using tissue tissue from a fine needle aspiration.
The test is designed to help classify "indeterminate" thyroid nodules, and therefore avoid avoid surgery for indeterminate nodules that are actually benign.
If the GEC test result is benign benign then the the sensitivity of the test is high enough to to achieve a negative predictive value of 94-95% in:
- atypical or follicular lesion of undetermined significance
- follicular neoplasm or lesion suggestive of follicular neoplasm
However, despite the improved classification, there is still a 5-10% risk of missing a malignant nodule on a biopsy sample that shows cytologically indeterminate cells that are suggestive of cancer. For these patients, repeat FNA or surgical resection should still be considered.
The GEC test does not have a role when there is a definitive result (either benign or malignant) on the original FNA aspiration.
-<p>A <strong>gene expression classifier </strong>(<strong>GEC</strong>) test is a developing technology in the pathologic analysis of thyroid nodules, using tissue from a <a title="Fine needle aspiration (FNA)" href="/articles/fine-needle-aspiration-fna">fine needle aspiration</a>.</p><p>The test is designed to help classify "indeterminate" thyroid nodules, and therefore avoid surgery for indeterminate nodules that are actually benign.</p><p>If the GEC test result is benign then the sensitivity of the test is high enough to achieve a negative predictive value of 94-95% in: </p><ul>- +<p>A <strong>gene expression classifier </strong>(<strong>GEC</strong>) test is a developing technology in the pathologic analysis of thyroid nodules, using tissue from a <a href="/articles/fine-needle-aspiration-fna">fine needle aspiration</a>.</p><p>The test is designed to help classify "indeterminate" <a href="/articles/assessment-of-thyroid-lesions-general">thyroid nodules</a>, and therefore avoid surgery for indeterminate nodules that are actually benign.</p><p>If the GEC test result is benign then the sensitivity of the test is high enough to achieve a negative predictive value of 94-95% in: </p><ul>
References changed:
- 1. Ali SZ, Fish SA, Lanman R et-al. Use of the afirma® gene expression classifier for preoperative identification of benign thyroid nodules with indeterminate fine needle aspiration cytopathology. PLoS Curr. 2013;5: . <a href="http://dx.doi.org/10.1371/currents.eogt.e557cbb5c7e4f66568ce582a373057e7">doi:10.1371/currents.eogt.e557cbb5c7e4f66568ce582a373057e7</a> - <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574863">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/23437421">Pubmed citation</a><span class="auto"></span>
- 2. Duick DS, Klopper JP, Diggans JC et-al. The impact of benign gene expression classifier test results on the endocrinologist-patient decision to operate on patients with thyroid nodules with indeterminate fine-needle aspiration cytopathology. Thyroid. 2012;22 (10): 996-1001. <a href="http://dx.doi.org/10.1089/thy.2012.0180">doi:10.1089/thy.2012.0180</a> - <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464064">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/22873825">Pubmed citation</a><span class="auto"></span>
- 3. Jameson JL. Minimizing unnecessary surgery for thyroid nodules. N. Engl. J. Med. 2012;367 (8): 765-7. <a href="http://dx.doi.org/10.1056/NEJMe1205893">doi:10.1056/NEJMe1205893</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/22731671">Pubmed citation</a><span class="auto"></span>
Tags changed:
- thyroid
Sections changed:
- Interventional Radiology
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