Question 2250
{"accessible":false,"alternatives":[{"id":11146,"text":"carries a poorer prognosis compared to individuals without pseudoprogression"},{"id":11147,"text":"cerebral blood volume in the enhancing areas is usually elevated"},{"id":11148,"text":"more commonly encountered in tumors with MGMT methylation"},{"id":11149,"text":"patients are typically more unwell than the imaging would suggest"},{"id":11150,"text":"typically occurs 2 or more years after treatment"}],"archived":false,"correctAlternativeId":11148,"explanation":"\u003cp\u003eO6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that is important in predicting the effects of alkylating chemotherapeutic agents (e.g. temozolomide) in the treatment of high-grade gliomas.\u0026nbsp;\u003c/p\u003e\u003cp\u003eWhen the MGMT promoter is methylated, there is decreased activity of MGMT, therefore less DNA repair, and thus alkylating agents are more effective. The identification of methylated-MGMT is a positive prognostic factor and increases the likelihood of\u0026nbsp;\u003ca href=\"/articles/tumour-pseudoprogression\"\u003epseudoprogression\u003c/a\u003e\u0026nbsp;following\u0026nbsp;\u003ca href=\"/articles/stupp-protocol-for-glioblastoma\"\u003eStupp protocol\u003c/a\u003e.\u003c/p\u003e\u003cp\u003eCerebral blood volume in pseudoprogression is usually low and patients are usually better clinically than the scan would suggest.\u0026nbsp;\u003c/p\u003e","id":2250,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2768","nextQuestionPath":"/articles/glioblastoma-idh-wildtype/questions/2249","relatedArticles":[{"id":32837,"title":"Methylguanine-DNA methyltransferase (MGMT)","link":"/articles/methylguanine-dna-methyltransferase-mgmt?lang=us"},{"id":34959,"title":"Tumor pseudoprogression (brain tumors)","link":"/articles/tumour-pseudoprogression-brain-tumors?lang=us"}],"alsoUsedIn":[{"id":1169,"kind":"Course","title":"Adult Neuroradiology Review Course - page 1169","link":"https://radiopaedia.org/courses/adult-neuroradiology-review-course/pages/1169"},{"id":1169,"kind":"Course","title":"Adult Neuroradiology Review Course - page 1169","link":"https://radiopaedia.org/courses/adult-brain-mri-review-course-2015-online-video/pages/1169"},{"id":1222,"kind":"Course","title":"Diffuse Gliomas Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/diffuse-gliomas-learning-pathway/pages/1222"},{"id":1222,"kind":"Course","title":"Brain Tumours Learning Pathway - page 1222","link":"https://radiopaedia.org/courses/brain-tumours-learning-pathway/pages/1222"}],"stem":"\u003cp\u003eWhich of the following statements is\u0026nbsp;\u003cstrong\u003eTRUE\u003c/strong\u003e\u0026nbsp;regarding pseudoprogression of high-grade gliomas?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/2250"}],"attemptsPercentages":[{"alternativeId":"11149","percentage":2},{"alternativeId":"11150","percentage":2},{"alternativeId":"11148","percentage":86},{"alternativeId":"11146","percentage":3},{"alternativeId":"11147","percentage":7}],"promptToLogin":false,"questionManager":false,"articleId":"glioblastoma-idh-wildtype"}