Question 2303
{"accessible":false,"alternatives":[{"id":11396,"text":"increase in apparent diffusion coefficient (ADC) values"},{"id":11397,"text":"increased contrast enhancement in the tumor"},{"id":11398,"text":"increased vasogenic edema surrounding the tumor"},{"id":11399,"text":"preserved elevation of relative cerebral blood volume (rCBV)"},{"id":11400,"text":"reduction in non-enhancing tumor"}],"archived":false,"correctAlternativeId":11399,"explanation":"\u003cp\u003ePseudoresponse, caused by bevacizumab (trade name Avastin,\u0026nbsp;an inhibitor of vascular endothelial growth factor) for example represents the reduction in enhancement and vasogenic edema largely mediated by changes in blood-brain barrier permeability rather than direct antiangiogenic effects. As such remaining tumor retains elevated rCBV and depressed ADC values (high cellularity). There is little effect on non-enhancing tumor, other than the reduction that can be attributed to edema.\u0026nbsp;\u003c/p\u003e","id":2303,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2768","nextQuestionPath":"/articles/glioblastoma-idh-wildtype/questions/2256","relatedArticles":[{"id":34958,"title":"Tumor pseudoresponse","link":"/articles/tumour-pseudoresponse?lang=us"}],"alsoUsedIn":[],"stem":"\u003cp\u003ePseudoresponse in glioblastoma is characterized by...\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/2303"}],"attemptsPercentages":[{"alternativeId":"11399","percentage":53},{"alternativeId":"11398","percentage":6},{"alternativeId":"11397","percentage":3},{"alternativeId":"11400","percentage":22},{"alternativeId":"11396","percentage":16}],"promptToLogin":false,"questionManager":false,"articleId":"glioblastoma-idh-wildtype"}