Question 613
{"accessible":false,"alternatives":[{"id":3072,"text":"extensive necrosis"},{"id":3073,"text":"IDH wild-type (not mutated)"},{"id":3074,"text":"lower ECOG performance status"},{"id":3075,"text":"MGMT methylated (inactive)"},{"id":3076,"text":"older age (\u003e70 years of age)"}],"archived":false,"correctAlternativeId":3075,"explanation":"\u003cp\u003eMGMT methylation (inactivity) makes tumors more susceptible to alkylating agents (e.g. temozolomide) and therefore a better prognosis. All the others are negative prognostic factors.\u0026nbsp;\u003c/p\u003e\u003cp\u003eNote: as of the 2021 WHO classification of CNS tumors, all glioblastomas are IDH-wildtype. An astrocytic tumor with IDH mutation and necrosis would be considered a grade 4 astrocytoma IDH-mutatnt. \u003c/p\u003e","id":613,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2768","nextQuestionPath":"/articles/glioblastoma-idh-wildtype/questions/609","relatedArticles":[{"id":23586,"title":"ECOG performance status","link":"/articles/ecog-performance-status?lang=us"},{"id":32837,"title":"Methylguanine-DNA methyltransferase (MGMT)","link":"/articles/methylguanine-dna-methyltransferase-mgmt?lang=us"},{"id":42300,"title":"Stupp protocol","link":"/articles/stupp-protocol?lang=us"},{"id":39154,"title":"Isocitrate dehydrogenase (IDH)","link":"/articles/isocitrate-dehydrogenase-idh-1?lang=us"}],"alsoUsedIn":[{"id":1169,"kind":"Course","title":"Adult Neuroradiology Review Course - page 1169","link":"https://radiopaedia.org/courses/adult-neuroradiology-review-course/pages/1169"},{"id":1169,"kind":"Course","title":"Adult Neuroradiology Review Course - page 1169","link":"https://radiopaedia.org/courses/adult-brain-mri-review-course-2015-online-video/pages/1169"}],"stem":"\u003cp\u003eWhich of the following is a good prognostic factor for glioblastoma (GBM)?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/613"}],"attemptsPercentages":[{"alternativeId":"3072","percentage":2},{"alternativeId":"3073","percentage":11},{"alternativeId":"3076","percentage":2},{"alternativeId":"3075","percentage":79},{"alternativeId":"3074","percentage":5}],"promptToLogin":false,"questionManager":false,"articleId":"glioblastoma-idh-wildtype"}