Question 658
{"accessible":false,"alternatives":[{"id":3296,"text":"far more common than primary glioblastomas"},{"id":3297,"text":"usually IDH mutant"},{"id":3298,"text":"more aggressive than primary glioblastomas"},{"id":3299,"text":"most often found in the temporal lobes"},{"id":3300,"text":"usually diagnosed in older individuals"}],"archived":false,"correctAlternativeId":3297,"explanation":"\u003cp\u003eSecondary glioblastomas\u0026nbsp;were those which arose from a pre-existing lower grade diffuse astrocytoma. They were relatively uncommon, only accounting for approximately 10% of all glioblastomas. These tumors tend to be less aggressive than primary glioblastomas and they tend to occur in younger patients.\u0026nbsp;\u003c/p\u003e\u003cp\u003eAs of the 2021 5th Edition of the WHO Classification of CNS tumors, the term is no longer relevant as glioblastomas are necessarily IDH-wildtype and thus equivalent to 'primary glioblastomas'.\u0026nbsp;\u003c/p\u003e\u003cp\u003eWhat was terms secondary glioblastoma is now essentially equivalent to a grade 4 astrocytoma IDH mutant.\u0026nbsp;\u003c/p\u003e","id":658,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2768","nextQuestionPath":"/articles/glioblastoma-idh-wildtype/questions/613","relatedArticles":[{"id":4986,"title":"Brain tumors","link":"/articles/brain-tumours?lang=us"},{"id":39154,"title":"Isocitrate dehydrogenase (IDH)","link":"/articles/isocitrate-dehydrogenase-idh-1?lang=us"}],"alsoUsedIn":[],"stem":"\u003cp\u003eHistorically, secondary glioblastomas were considered...\u0026nbsp;\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/658"}],"attemptsPercentages":[{"alternativeId":"3299","percentage":8},{"alternativeId":"3300","percentage":18},{"alternativeId":"3296","percentage":7},{"alternativeId":"3297","percentage":42},{"alternativeId":"3298","percentage":25}],"promptToLogin":false,"questionManager":false,"articleId":"glioblastoma-idh-wildtype"}