Hemochromatosis (cardiac manifestations)
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Cardiac involvement in haemochromatosis can affect approximately 15-20% of haemochromatosis.
Pathology
Haemochromatosis can result in an iron overload cardiomyopathy.
Clinical presentation
Manifestations depend upon the extent of iron deposition and include
- breathlessness
- pedal oedema
- palpitations
- features of congestive heart failure
Radiographic features
Echocardiography
Non specific but may show a decrease in systolic function and/or ejection fraction. May also show evidence of a dilated cardiomyopathy
MRI
Role of MRI is to identify and quantify the amount of iron deposition . Paramagnetic ferritin and haemosiderin leads to altered relaxation times of adjacent hydrogen nuclei. T2* imaging is highly sensitve in detecting the amount of iron deposition . T2* CMR is also a recent advancement in evaluation of cardiac iron overload.
-<p><strong>Cardiac involvement in haemochromatosis</strong> can affect approximately 15-20% of <a href="/articles/haemochromatosis">haemochromatosis</a>. </p><h4>Pathology</h4><p>Haemochromatosis can result in an<a title="iron overload cardiomyopathy" href="/articles/iron-overload-cardiomyopathy"> iron overload cardiomyopathy</a>.</p><h4><strong>Clinical presentation</strong></h4><p>Manifestations depend upon the extent of iron deposition and include</p><ul>- +<p><strong>Cardiac involvement in haemochromatosis</strong> can affect approximately 15-20% of <a href="/articles/haemochromatosis">haemochromatosis</a>. </p><h4>Pathology</h4><p>Haemochromatosis can result in an<a href="/articles/iron-overload-cardiomyopathy"> iron overload cardiomyopathy</a>.</p><h4><strong>Clinical presentation</strong></h4><p>Manifestations depend upon the extent of iron deposition and include</p><ul>
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