Histiocytic sarcoma
Last revised by Frank Gaillard on 21 Oct 2021
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Iqbal S, Elfeky M, et al. Histiocytic sarcoma. Reference article, Radiopaedia.org (Accessed on 20 Apr 2024) https://doi.org/10.53347/rID-48058
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rID:
48058
Article created:
17 Sep 2016,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosures
Revisions:
8 times, by
6 contributors -
see full revision history and disclosures
Systems:
Synonyms:
- Histiocytic sarcomas
- Histiocytic sarcoma (HS)
Histiocytic sarcoma is a rare malignant hematopoietic neoplasm that has been reported in association with other hematological malignancies (particularly B and T cell lymphomas).
On this page:
Pathology
It comprises of tumor cells derived from the monocyte/macrophage lineage.
Location
It usually occurs in lymph nodes, skin, and the gastrointestinal tract. Occurrence in the CNS system has also been rarely reported 3.
Prognosis
The overall prognosis is generally poor due to rapid progression and poor response to therapy. Tumor size may be a prognostic factor.
History and etymology
It was first described by Mathé et al. in 1970.
See also
References
- 1. Chalasani S, Hennick MR, Hocking WG et-al. Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. Clin Med Res. 2013;11 (1): 31-5. doi:10.3121/cmr.2012.1092 - Free text at pubmed - Pubmed citation
- 2. Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am. J. Surg. Pathol. 2004;28 (9): 1133-44. Pubmed citation
- 3. Laviv Y, Zagzag D, Fichman-Horn S et-al. Primary central nervous system histiocytic sarcoma. Brain Tumor Pathol. 2013;30 (3): 192-5. doi:10.1007/s10014-012-0123-z - Pubmed citation
- 4. Hung Y & Qian X. Histiocytic Sarcoma. Arch Pathol Lab Med. 2020;144(5):650-4. doi:10.5858/arpa.2018-0349-RS - Pubmed
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