Hypervitaminosis A

Changed by Henry Knipe, 16 Sep 2014

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Hypervitaminosis A results from an excess of vitamin A. It usually manifests on children and one recognised cause is administration from 13-cis retinoic acid for treatment of cancers such as neuroblastoma.

Pathology

Manifestations can differ depending on whether it is an acute or chronic excess of vitamin A.

Acute

pseudotumour cerebri

Chronic

pruritus, dry skin, dry lips
soft tissue nodules
diffuse symmetric periostitis (scintigraphy may allow earlier detection ²)
may cause premature fusion of ossification centers
separation of cranial sutures
hepatosplenomegaly
tendinous/ligamentous calcifications

Differential diagnosis

infantile cortical hyperostosis (Caffey's disease): for skeletal manifestations.

~~-<a href="/articles/caffey-disease-1">infantile cortical hyperostosis</a> (Caffey's disease): for skeletal manifestations. </li></ul>~~
+<a href="/articles/caffey-disease-1">infantile cortical hyperostosis</a> (Caffey's disease): for skeletal manifestations</li></ul>

References changed:

1. Miller J & Hayon I. Bone Scintigraphy in Hypervitaminosis A. AJR Am J Roentgenol. 1985;144(4):767-8. <a href="https://doi.org/10.2214/ajr.144.4.767">doi:10.2214/ajr.144.4.767</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/3872035">Pubmed</a>
2. Pennes D, Ellis C, Madison K, Voorhees J, Martel W. Early Skeletal Hyperostoses Secondary to 13-Cis-Retinoic Acid. AJR Am J Roentgenol. 1984;142(5):979-83. <a href="https://doi.org/10.2214/ajr.142.5.979">doi:10.2214/ajr.142.5.979</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/6609585">Pubmed</a>

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