Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Bell D, Immune mediated necrotizing myopathy. Reference article, Radiopaedia.org (Accessed on 27 Apr 2024) https://doi.org/10.53347/rID-148835
Immune mediated necrotizing myopathy (IMNM) is classified as a form or myopathy and sometimes a form of myositis.
Associations
It is clinically characterized by a subacute muscle weakness (primarily proximal limbs and trunk) in combination with elevated levels of serum creatine kinase (CK) levels.
Immune mediated necrotizing myopathy may result in severe and extensive lower limb muscle edema, fatty replacement and atrophy.
Distribution
The pelvic muscles and adductors are thought to be more involved in immune mediated necrotizing myopathy compared to conditions such as polymyositis or dermatomyositis 1.
Markers
Consider
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1. Day J, Bajic N, Gentili S, Patel S, Limaye V. Radiographic Patterns of Muscle Involvement in the Idiopathic Inflammatory Myopathies. Muscle Nerve. 2019;60(5):549-57. doi:10.1002/mus.26660 - Pubmed
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2. Tanino Y. Interstitial Lung Disease Is a Possible Manifestation of Anti-Signal Recognition Particle Antibody Syndrome. Intern Med. 2018;57(14):1957-8. doi:10.2169/internalmedicine.0662-17 - Pubmed
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3. Pinal-Fernandez I, Casal-Dominguez M, Carrino J et al. Thigh Muscle MRI in Immune-Mediated Necrotising Myopathy: Extensive Oedema, Early Muscle Damage and Role of Anti-SRP Autoantibodies as a Marker of Severity. Ann Rheum Dis. 2017;76(4):681-7. doi:10.1136/annrheumdis-2016-210198 - Pubmed
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4. Ma X, Xu L, Ji S, Li Y, Bu B. The Clinicopathological Distinction Between Seropositive and Seronegative Immune-Mediated Necrotizing Myopathy in China. Front Neurol. 2021;12:670784. doi:10.3389/fneur.2021.670784 - Pubmed
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5. Yang H, Tian X, Zhang L et al. Clinical and Pathological Features of Immune-Mediated Necrotising Myopathies in a Single-Centre Muscle Biopsy Cohort. BMC Musculoskelet Disord. 2022;23(1):425. doi:10.1186/s12891-022-05372-z - Pubmed
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6. Polte C, Bergh N, Oldfors A, Hanna B, Bollano E. Cardiac Involvement in Immune-Mediated Necrotizing Myopathy: Insights from CMR and Somatostatin Receptor PET/CT. European Heart Journal - Cardiovascular Imaging. 2021;23(5):e237. doi:10.1093/ehjci/jeab262 - Pubmed
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7. Thiébaut M, Terrier B, Menacer S et al. Antisignal Recognition Particle Antibodies–Related Cardiomyopathy. Circulation. 2013;127(5). doi:10.1161/circulationaha.112.118877
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