Question 326
{"accessible":false,"alternatives":[{"id":1591,"text":"deep location"},{"id":1592,"text":"IDH mutant (positive)"},{"id":1593,"text":"MGMT methylation"},{"id":1595,"text":"younger age at diagnosis"}],"archived":false,"correctAlternativeId":1591,"explanation":"\u003cp\u003eDeep location, such as the\u0026nbsp;thalamus, has a poor prognosis. The other alternatives are all markers of better prognosis. It is important to note that in all cases the diagnosis remains poor.\u003c/p\u003e\u003cp\u003eIt is important to note that a tumor with IDH mutation would now (since the 2021 WHO classification of CNS tumors) be considered a grade 4 astrocytoma IDH-mutant rather than glioblastoma; these have a comparatively better prognosis.\u003c/p\u003e\u003cp\u003eMGMT methylation is a good prognostic factor as these tumors are more likely to respond favourably to \u003ca href=\"/articles/stupp-protocol-for-glioblastoma\" title=\"Stupp protocol for glioblastoma\"\u003eStupp protocol\u003c/a\u003e.\u003c/p\u003e\u003cp\u003e\u003c/p\u003e\u003cp\u003e\u003c/p\u003e\u003cp\u003e\u003c/p\u003e\u003cp\u003e\u003c/p\u003e\u003cp\u003e\u003c/p\u003e","id":326,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2841","nextQuestionPath":"/articles/isocitrate-dehydrogenase-idh-1/questions/15","relatedArticles":[{"id":4910,"title":"Glioblastoma, IDH-wildtype","link":"/articles/glioblastoma-idh-wildtype?lang=us"},{"id":32837,"title":"Methylguanine-DNA methyltransferase (MGMT)","link":"/articles/methylguanine-dna-methyltransferase-mgmt?lang=us"}],"alsoUsedIn":[],"stem":"\u003cp\u003eIn a patient with a diagnosis of glioblastoma (GBM), which of the following are poor prognostic features?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/326"}],"attemptsPercentages":[{"alternativeId":"1594","percentage":5},{"alternativeId":"1595","percentage":15},{"alternativeId":"1593","percentage":16},{"alternativeId":"1591","percentage":44},{"alternativeId":"1592","percentage":19}],"promptToLogin":false,"questionManager":false,"articleId":"isocitrate-dehydrogenase-idh"}