Question 562
{"accessible":false,"alternatives":[{"id":2815,"text":"GFAP"},{"id":2816,"text":"IDH-1 mutation"},{"id":2817,"text":"NeuN"},{"id":2818,"text":"NOGO-A"},{"id":2819,"text":"S100"}],"archived":false,"correctAlternativeId":2816,"explanation":"\u003cp\u003eImportantly, DNETs are negative for IDH mutations which is helpful in distinguishing DNETs from astrocytomas (IDH-mutant). This is particularly useful as larger DNETs can have a bright rim appearance and central FLAIR suppression similar to some astrocytomas (previously known as protoplasmic astrocytomas).\u003c/p\u003e\u003cp\u003e\u0026nbsp;NeuN is a marker of neurons.\u003c/p\u003e\u003cp\u003eWhile NOGO-A is primarily found in oligodendrocytes and myelin, its inhibitory effects on axonal regeneration also impact neurons.\u003c/p\u003e\u003cp\u003eS100 is found in numerous tumors both within the central nervous system and elsewhere.\u003c/p\u003e\u003cp\u003eGFAP is the building block for intermediate filaments which are abundant in the cytoplasms particularly of \u003ca href=\"https://radiopaedia.org/articles/astrocytes\"\u003eastrocytes\u003c/a\u003e.\u0026nbsp;\u003c/p\u003e","id":562,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/2841","nextQuestionPath":"/articles/isocitrate-dehydrogenase-idh-1/questions/326","relatedArticles":[{"id":1251,"title":"Dysembryoplastic neuroepithelial tumor","link":"/articles/dysembryoplastic-neuroepithelial-tumour?lang=us"},{"id":52074,"title":"S100","link":"/articles/s100?lang=us"},{"id":51742,"title":"Glial fibrillary acid protein (GFAP)","link":"/articles/glial-fibrillary-acid-protein-gfap?lang=us"},{"id":24230,"title":"Protoplasmic astrocytoma (historical)","link":"/articles/protoplasmic-astrocytoma-historical?lang=us"},{"id":174012,"title":"Neuronal nuclear antigen (NeuN)","link":"/articles/neuronal-nuclear-antigen-neun?lang=us"}],"alsoUsedIn":[{"id":1747,"kind":"Course","title":"Epileptogenic Brain Tumours Learning Pathway - page 1747","link":"https://radiopaedia.org/courses/epileptogenic-brain-tumours-learning-pathway/pages/1747"}],"stem":"\u003cp\u003eUsing immunohistochemistry, dysembryoplastic neuroepithelial tumors (DNETs) are usually positive for all of the following\u0026nbsp;\u003cstrong\u003eEXCEPT\u003c/strong\u003e:\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/562"}],"attemptsPercentages":[{"alternativeId":"2815","percentage":8},{"alternativeId":"2818","percentage":9},{"alternativeId":"2819","percentage":10},{"alternativeId":"2817","percentage":8},{"alternativeId":"2816","percentage":65}],"promptToLogin":false,"questionManager":false,"articleId":"isocitrate-dehydrogenase-idh"}