Question 902
{"accessible":false,"alternatives":[{"id":4536,"text":"bone"},{"id":4537,"text":"central nervous system"},{"id":4538,"text":"liver"},{"id":4539,"text":"lung"},{"id":4540,"text":"skin"}],"archived":false,"correctAlternativeId":4536,"explanation":"\u003cp\u003e\u003ca title=\"Langerhans cell histiocytosis\" class=\"internal\" href=\"/articles/langerhans-cell-histiocytosis\"\u003eLangerhans cell histiocytosis\u003c/a\u003e\u0026nbsp;is a rare multi-system disease seen in young children characterized by clonal proliferation of Langerhans cells. The most commonly affected 'system' is the \u003ca title=\"Langerhans cell histiocytosis (skeletal manifestations)\" class=\"internal\" href=\"/articles/langerhans-cell-histiocytosis-skeletal-manifestations-1\"\u003eskeletal system\u003c/a\u003e, which is involved in nearly 80% of cases, followed by skin (~40%), liver (~15%), spleen (~15%), \u003ca title=\"Pulmonary Langerhans cell histiocytosis\" class=\"internal\" href=\"/articles/pulmonary-langerhans-cell-histiocytosis\"\u003elungs\u003c/a\u003e (~10%), and finally the \u003ca title=\"Langerhans cell histiocytosis (CNS manifestations)\" class=\"internal\" href=\"/articles/langerhans-cell-histiocytosis-cns-manifestations\"\u003eCNS\u003c/a\u003e (~5%).\u0026nbsp;\u003c/p\u003e","id":902,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/1099","nextQuestionPath":null,"relatedArticles":[{"id":5018,"title":"Pulmonary Langerhans cell histiocytosis","link":"/articles/pulmonary-langerhans-cell-histiocytosis?lang=us"},{"id":8478,"title":"Langerhans cell histiocytosis (skeletal manifestations)","link":"/articles/langerhans-cell-histiocytosis-skeletal-manifestations-1?lang=us"},{"id":55531,"title":"Langerhans cell histiocytosis (CNS manifestations)","link":"/articles/langerhans-cell-histiocytosis-cns-manifestations?lang=us"}],"alsoUsedIn":[],"stem":"\u003cp\u003eWhich of the following is most commonly involved in Langerhans cell histiocytosis in children?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/902"}],"attemptsPercentages":[{"alternativeId":"4536","percentage":86},{"alternativeId":"4537","percentage":5},{"alternativeId":"4540","percentage":3},{"alternativeId":"4538","percentage":1},{"alternativeId":"4539","percentage":6}],"promptToLogin":false,"questionManager":false,"articleId":"langerhans-cell-histiocytosis"}