Question 903
{"accessible":false,"alternatives":[{"id":4541,"text":"ataxia"},{"id":4542,"text":"bitemporal hemianopia"},{"id":4543,"text":"dementia"},{"id":4544,"text":"diabetes insipidus"},{"id":4545,"text":"hydrocephalus"}],"archived":false,"correctAlternativeId":4544,"explanation":"\u003cp\u003e\u003ca href=\"/articles/langerhans-cell-histiocytosis-cns-manifestations\"\u003eCNS manifestations of Langerhans cell histiocytosis (LCH)\u003c/a\u003e\u0026nbsp;are rare, present in only 6% of all cases. The disease has a predilection for the\u0026nbsp;\u003ca href=\"https://radiopaedia.org/articles/missing?article%5Btitle%5D=hypothalamic-pituitary-axis\"\u003ehypothalamic-pituitary axis\u003c/a\u003e,\u0026nbsp;\u003ca href=\"https://radiopaedia.org/articles/cerebellum\"\u003ecerebellum\u003c/a\u003e, and\u0026nbsp;\u003ca href=\"https://radiopaedia.org/articles/basal-ganglia\"\u003ebasal ganglia\u003c/a\u003e, however can rarely present in other areas of the brain, meninges and brainstem causing either degeneration or masses. Thus, the\u0026nbsp;most common clinical manifestation is central \u003ca href=\"/articles/diabetes-insipidus\"\u003ediabetes insipidus\u003c/a\u003e, followed by a neurodegenerative syndrome characterized by dementia and ataxia, and in rare instances, obstructive \u003ca href=\"/articles/hydrocephalus\"\u003ehydrocephalus\u003c/a\u003e may be present. Despite \u003ca href=\"/articles/pituitary-gland\"\u003epituitary gland\u003c/a\u003e involvement being common, bitemporal hemianopia is not a feature of LCH, because the gland is of a normal size (c.f. \u003ca title=\"Pituitary macroadenoma\" class=\"internal\" href=\"/articles/pituitary-macroadenoma-1\"\u003epituitary macroadenoma\u003c/a\u003e) and only the \u003ca href=\"/articles/pituitary-stalk\"\u003einfundibulum\u003c/a\u003e is thickened.\u003c/p\u003e","id":903,"imageUrl":null,"imageAttribution":null,"imageAttributionCaseInfo":null,"firstQuestionPath":"/questions/1099","nextQuestionPath":"/articles/langerhans-cell-histiocytosis/questions/902","relatedArticles":[{"id":42150,"title":"Diabetes insipidus","link":"/articles/diabetes-insipidus?lang=us"},{"id":55531,"title":"Langerhans cell histiocytosis (CNS manifestations)","link":"/articles/langerhans-cell-histiocytosis-cns-manifestations?lang=us"}],"alsoUsedIn":[],"stem":"\u003cp\u003eWhat is the most common clinical manifestation of CNS involvement in Langerhans cell histiocytosis?\u003c/p\u003e","menuLinks":[{"text":"Report problem with question","url":"https://docs.google.com/forms/d/e/1FAIpQLSfO3soWYhOjJ7yErSysyCe5V4A1CqW7WK3rDA7MtAkecMGqNw/viewform?entry.1624461248\u0026entry.553583435=https://radiopaedia.org/questions/903"}],"attemptsPercentages":[{"alternativeId":"4542","percentage":7},{"alternativeId":"4544","percentage":81},{"alternativeId":"4545","percentage":4},{"alternativeId":"4541","percentage":7},{"alternativeId":"4543","percentage":1}],"promptToLogin":false,"questionManager":false,"articleId":"langerhans-cell-histiocytosis"}