Lepidic-predominant adenocarcinoma of the lung
Updates to Article Attributes
Lepidic-predominant adenocarcinoma (LPA) of the lung, formerly known as non-mucinous bronchoalveolar carcinoma, is a subtype of invasive adenocarcinoma of the lung characterised histologically when the lepidic component comprises the majority of the lesion.
Terminology
The category of 'lepid predominant adenocarcinoma' now replaces 'non-mucinous bronchoalveolar carcinoma' of the lung.
In 2011, the International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) 2 introduced a new classification and terminology for adenocarcinoma of the lung, which is now divided into 'preinvasive', 'minimally invasive', and 'invasive'.
The term bronchoalveolar carcinoma (BAC) has been retired, and it is recommended that all invasive adenocarcinomas be classified in terms of the "predominant" comprising histology 2. Both mucinous and non-mucinous adenocarcinomas typically consist of a mixture of histologic patterns, but reporting of the predominant subtype is specifically recommended for non-mucinous lesions, with all mucinous tumours placed in a separate category.
Pathology
Invasive adenocarcinoma is defined as a lesion with >5 mm of invasion into the normal surrounding lung (i.e. lymphatics, pleura, or blood vessels) and/or the presence of tumour necrosis on the basis of histology of the surgical resection specimen. The non-mucinous disease is further assessed for any histologic patterns within the lesion (lepidic, acinar, papillary, micropapillary, and solid growth), and the "predominant" subtype is reported 2.
Thus, lepidic predominant invasive adenocarcinomas show a predominance of bland pneumocytic-type neoplastic cells with growth along normal structures e.g. alveoli.
Radiographic features
CT
While not specific CT feature specific for this sub-type has been reported (as of 2018), some studies suggest some features may show increased chance of invasiveness associated with these tumours, these include 4
- increasing maximum diameter of the whole lesion (ground glass and solid component)
- larger diameter of the solid component / higher visual estimated percentage solid component compared to whole lesion
History and etymology
The term lepidic means "scaly", and is used by pathologists to describe the growth of neoplastic cells crawling along the covering "scaly" layer of normal lung architecture 2.
-<p><strong>Lepidic-predominant adenocarcinoma (LPA) of the lung</strong>, formerly known as <strong>non-mucinous bronchoalveolar carcinoma</strong>, is a subtype of <a href="/articles/adenocarcinoma-of-the-lung">invasive adenocarcinoma of the lung</a> characterised histologically when the lepidic component comprises the majority of the lesion.</p><h4>Terminology</h4><p>The category of 'lepid predominant adenocarcinoma' now replaces 'non-mucinous bronchoalveolar carcinoma' of the lung. </p><p>In 2011, the International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) <sup>2</sup> introduced a new classification and terminology for adenocarcinoma of the lung, which is now divided into 'preinvasive', 'minimally invasive', and 'invasive'. </p><p>The term <a href="/articles/adenocarcinoma-in-situ-minimally-invasive-adenocarcinoma-and-invasive-adenocarcinoma-of-lung">bronchoalveolar carcinoma (BAC)</a> has been retired, and it is recommended that all invasive adenocarcinomas be classified in terms of the "predominant" comprising histology <sup>2</sup>. Both mucinous and non-mucinous adenocarcinomas typically consist of a mixture of histologic patterns, but reporting of the predominant subtype is specifically recommended for non-mucinous lesions, with all <a href="/articles/invasive-mucinous-adenocarcinoma-of-the-lung-1">mucinous tumours</a> placed in a separate category.</p><h4>Pathology</h4><p>Invasive adenocarcinoma is defined as a lesion with >5 mm of invasion into the normal surrounding lung (i.e. lymphatics, pleura, or blood vessels) and/or the presence of tumour necrosis on the basis of histology of the surgical resection specimen. The non-mucinous disease is further assessed for any histologic patterns within the lesion (lepidic, acinar, papillary, micropapillary, and solid growth), and the "predominant" subtype is reported <sup>2</sup>.</p><p>Thus, lepidic predominant invasive adenocarcinomas show a predominance of bland pneumocytic-type neoplastic cells with growth along normal structures e.g. alveoli.</p><h4>History and etymology</h4><p>The term <em>lepidic</em> means "scaly", and is used by pathologists to describe the growth of neoplastic cells crawling along the covering "scaly" layer of normal lung architecture <sup>2</sup>.</p>- +<p><strong>Lepidic-predominant adenocarcinoma (LPA) of the lung</strong>, formerly known as <strong>non-mucinous bronchoalveolar carcinoma</strong>, is a subtype of <a href="/articles/adenocarcinoma-of-the-lung">invasive adenocarcinoma of the lung</a> characterised histologically when the lepidic component comprises the majority of the lesion.</p><h4>Terminology</h4><p>The category of 'lepid predominant adenocarcinoma' now replaces 'non-mucinous bronchoalveolar carcinoma' of the lung. </p><p>In 2011, the International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS), and European Respiratory Society (ERS) <sup>2</sup> introduced a new classification and terminology for adenocarcinoma of the lung, which is now divided into 'preinvasive', 'minimally invasive', and 'invasive'. </p><p>The term <a href="/articles/adenocarcinoma-in-situ-minimally-invasive-adenocarcinoma-and-invasive-adenocarcinoma-of-lung">bronchoalveolar carcinoma (BAC)</a> has been retired, and it is recommended that all invasive adenocarcinomas be classified in terms of the "predominant" comprising histology <sup>2</sup>. Both mucinous and non-mucinous adenocarcinomas typically consist of a mixture of histologic patterns, but reporting of the predominant subtype is specifically recommended for non-mucinous lesions, with all <a href="/articles/invasive-mucinous-adenocarcinoma-of-the-lung-1">mucinous tumours</a> placed in a separate category.</p><h4>Pathology</h4><p>Invasive adenocarcinoma is defined as a lesion with >5 mm of invasion into the normal surrounding lung (i.e. lymphatics, pleura, or blood vessels) and/or the presence of tumour necrosis on the basis of histology of the surgical resection specimen. The non-mucinous disease is further assessed for any histologic patterns within the lesion (lepidic, acinar, papillary, micropapillary, and solid growth), and the "predominant" subtype is reported <sup>2</sup>.</p><p>Thus, lepidic predominant invasive adenocarcinomas show a predominance of bland pneumocytic-type neoplastic cells with growth along normal structures e.g. alveoli.</p><h4>Radiographic features</h4><h5>CT</h5><p>While not specific CT feature specific for this sub-type has been reported (as of 2018), some studies suggest some features may show increased chance of invasiveness associated with these tumours, these include <sup>4</sup></p><ul>
- +<li>increasing maximum diameter of the whole lesion (ground glass and solid component) </li>
- +<li>larger diameter of the solid component / higher visual estimated percentage solid component compared to whole lesion</li>
- +</ul><h4>History and etymology</h4><p>The term <em>lepidic</em> means "scaly", and is used by pathologists to describe the growth of neoplastic cells crawling along the covering "scaly" layer of normal lung architecture <sup>2</sup>.</p>
References changed:
- 4. Aherne EA, Plodkowski AJ, Montecalvo J, Hayan S, Zheng J, Capanu M, Adusumilli PS, Travis WD, Ginsberg MS. What CT characteristics of lepidic predominant pattern lung adenocarcinomas correlate with invasiveness on pathology?. (2018) Lung cancer (Amsterdam, Netherlands). 118: 83-89. <a href="https://doi.org/10.1016/j.lungcan.2018.01.013">doi:10.1016/j.lungcan.2018.01.013</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/29572008">Pubmed</a> <span class="ref_v4"></span>
- 5. Duruisseaux M, Antoine M, Rabbe N, Rodenas A, Mc Leer-Florin A, Lacave R, Poulot V, Duchêne B, Van Seuningen I, Cadranel J, Wislez M. Lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma of the lung exhibit specific mucin expression in relation with oncogenic drivers. (2017) Lung cancer (Amsterdam, Netherlands). 109: 92-100. <a href="https://doi.org/10.1016/j.lungcan.2017.05.007">doi:10.1016/j.lungcan.2017.05.007</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/28577958">Pubmed</a> <span class="ref_v4"></span>
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