Li-Fraumeni syndrome
Updates to Article Attributes
Body
was changed:
Li-Fraumeni syndrome is a hereditary cancer syndrome due to mutations in the tumour suppressor gene TP53. Approximately half of affected individuals are thought to develop invasive cancer by 30 years of age 1.
Associated malignancies
- sarcomas
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CNS tumours
- gliomas
- choroid plexus carcinoma
- medulloblastoma
- neuroectodermal tumours
- leukaemia
- breast cancer
- adrenal cortical carcinoma
-<p><strong>Li-Fraumeni syndrome</strong> is a hereditary cancer syndrome due to mutations in the tumour suppressor gene <a title="TP53" href="/articles/tp53">TP53</a>. Approximately half of affected individuals are thought to develop invasive cancer by 30 years of age <sup>1</sup>.</p><h4>Associated malignancies</h4><ul>- +<p><strong>Li-Fraumeni syndrome</strong> is a hereditary cancer syndrome due to mutations in the tumour suppressor gene <em><a href="/articles/tp53-gene-1">TP53</a></em>. Approximately half of affected individuals are thought to develop invasive cancer by 30 years of age <sup>1</sup>.</p><h4>Associated malignancies</h4><ul>
References changed:
- 1. Shinagare AB, Giardino AA, Jagannathan JP et-al. Hereditary cancer syndromes: a radiologist's perspective. AJR Am J Roentgenol. 2011;197 (6): W1001-7. <a href="http://dx.doi.org/10.2214/AJR.11.6465">doi:10.2214/AJR.11.6465</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/22109313">Pubmed citation</a><span class="ref_v3"></span>
- 1- Shinagare AB, Giardino AA, Jagannathan JP et-al. Hereditary cancer syndromes: a radiologist's perspective. AJR Am J Roentgenol. 2011;197 (6): W1001-7. <a href="http://dx.doi.org/10.2214/AJR.11.6465">doi:10.2214/AJR.11.6465</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/22109313">Pubmed citation</a><span class="ref_v3"></span>
Sections changed:
- Syndromes
Systems changed:
- Haematology
Updates to Synonym Attributes
Title
was changed:
Li-Fraumeni Fraumeni syndrome
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