Mannose-binding lectin deficiency

Last revised by Daniel J Bell on 3 Apr 2020

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Bell D, Tatco V, et al. Mannose-binding lectin deficiency. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-31652

DOI:

https://doi.org/10.53347/rID-31652

Permalink:

https://radiopaedia.org/articles/31652

rID:

31652

Article created:

19 Oct 2014, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

3 Apr 2020, Daniel J Bell ◉

Disclosures:

At the time the article was last revised Daniel J Bell had no recorded disclosures.

View Daniel J Bell's current disclosures

Revisions:

4 times, by 4 contributors - see full revision history and disclosures

Systems:

Haematology

Synonyms:

MBL deficiency
Mannose-binding lectin (MBL) deficiency
MBL2 deficiency
MBP deficiency
Mannose-binding protein deficiency

Mannose-binding lectin deficiency is a condition that affects the immune system.

Epidemiology

It may be prevalent in 10-30% of the general population.

Associations

disease progression in cystic fibrosis ¹
severe disease in those with bronchiectasis without underlying cystic fibrosis
more severe progression in those with spondyloarthropathies such as ankylosing spondylitis ³

Pathology

Affected individuals have low levels of an immune protein named mannose-binding lectin in their blood. They are prone to recurrent infections, including infections of the upper respiratory tract and other body systems.