Mediastinum

The mediastinum is a space in the thorax that contains a group of organs, vessels, nerves, lymphatics and their surrounding connective tissue. It lies in the midline of the chest between the pleura of each lung and extends from the sternum to the vertebral column. 

Gross anatomy

The mediastinum contains all the thoracic viscera except the lungs: heart and great vessels, internal mammary vessels, proximal aspect of azygos venous system, oesophagus, trachea, phrenic nerve, cardiac nerve, supra-aortic and para-aortic bodies, thoracic duct, thymus, and mediastinal lymph nodes.

Anatomical division

Division of the mediastinum is generally conceptualized as comprising 3three or 4four compartments, depending on the schema. For example, the mediastinum can be divided into parts based on their relationship to the fibrous pericardium:

• superior mediastinum: above the upper level of the pericardium and plane of Ludwig
• inferior mediastinum: below the plane of Ludwig
  • anterior mediastinum: anterior to the pericardium
  • middle mediastinum: within the pericardium
  • posterior mediastinum: posterior to the pericardium ⁸

Historically, there have been discrepant definitions of the mediastinal compartments between medical disciplines. For example, radiologists originally used arbitrary radiologic landmarks on lateral radiographs, while surgeons considered the mediastinum according to anatomic limits encountered intraoperatively (e.g. Shields classification). In response, there have been efforts to reconcile mediastinal classification systems for consistency.². 

The more modern ITMIG classification system, developed in by a multidisciplinary group including radiologists and thoracic surgeons, relies on CT-based anatomic divisions³.³  It divides dethe mediastinum ininto three compartments with the following boundaries:

• Pré-vascularprevascular mediastinum: 
  • Superior limitsuperior: the thoracic inlet
  • Inferior limitinferior: the diaphragm
  • Lateral limitslateral: parietal mediastinal pleura
  • Posterior limitposterior: anterior aspectoaspect of the pericardium.
• Visceralvisceral mediastinum:
  • Superior limitsuperior: thoracic inlet
  • Inferior limitinferior: the diaphragm
  • Anterior limitanterior: the posterior boundaries of the prevascular compartment.
• Paravertebralparavertebral mediastinum: 
  • Superior limitsuperior: thoracic inlet
  • Inferior limitinferior: the diaphragm
  • Anterior limitanterior: posterior boundaries of the visceral compartment
  • Posterior limitposterior: a vertical line along the posterior margin of the chest wall at the lateral aspect of the transverse processes. 

Pathology

Broadly, pathology that affects the mediastinum can be divided into those that result in a focal mass, or those that result in diffuse disease involving the mediastinum.

The differential diagnosis of a mediastinal mass is highly dependent on its location within the mediastinum, as this may reveal the structure of origin. Thus, there is a specific differential diagnosis for each compartment:

• thoracic inlet masses
• anterior mediastinal masses
• middle mediastinal masses
• posterior mediastinal masses

In cases where localisation is difficult due involvement of multiple compartments, the ITMIG recommends a "centre method" technique by which the central point on the axial slice where the lesion appears largest is used for localisation.³. Alternatively, a "structure displacement" technique whereby displacement of organs from adjacent compartments may be used to localise the lesion.⁴.

Diffuse mediastinal disease can can be separated into groups depending on whether the mediastinal disease is smooth or lobulated:

• smooth
  • mediastinal lipomatosis
  • mediastinal malignant infiltration
  • mediastinal haemorrhage
  • mediastinitis
• lobulated
  • mediastinal lymphadenopathy
  • thymic mass
  • germ cell neoplasm
  • mediastinal vascular abnormality
  • mediastinal neurofibromatosis

Finally, air tracking into the potential mediastinal spaces (pneumomediastinum) may occur when there is rupture of an air-containing structure, penetrating injury, or may be iatrogenic.