Meta-analysis

Last revised by Francesco Sciacca on 30 Jan 2024

Meta-analysis (plural: meta-analyzes) is a statistical technique that returns in a single numerical estimate (synthesis) the results of multiple clinical trials relating, for example, to the same pharmacological treatment 1,2. Meta-analyzes of RCTs specifically, are the most robust evidence of evidence based medicine (EBM) 3. Characteristic of meta-analyzes is that they must always be preceded by systematic reviews 4,5. The homogeneity of the studies included in the systematic review is of fundamental importance, otherwise developing a meta-analysis is not correct; in these cases it is better to favor qualitative approaches 6.

History and etymology

The term meta-analysis was coined by the American statistician and researcher Gene V Glass in 1976 2.

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