Neuroblastoma (craniocerebral metastases)
Updates to Article Attributes
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was changed:
Craniocerebral neuroblastoma metastases neuroblastoma metastases usually involve the calvaria, orbits, skull base and the dura.
Please refer to the the article neuroblastoma for a general discussion on this entity.
Clinical presentation
- proptosis
- periorbital ecchymosis "raccoon eyes"
- palpable calvarial masses
Radiographic features
CT
- spiculated periorbital bone mass, typically involving the roof or lateral wall/sphenoid wings
- "hair on end" spiculated periostitis of orbits and skull usually associated with bone destruction
- sutural separation: non
uniform-uniform suturalseparationseparation with indistinct sutures margins - cranial metastasis nearly always
extra-duralextradural (may mimic epidural or subdural hematoma)
MRI
- T1: hypointense to muscles
- T2: heterogeneous usually hyperintense to muscles
-
T1
CC+ (Gd): vigorously enhances, may be heterogeneous - MRV: may narrow or invade adjacent dural sinuses
Nuclear medicine
- MIBG (meta-iodo benzyl guanidine): avid uptake by neural crest tumours
- TC-99-m-MDP: shows increased uptake from calcium metabolism of tumour
- PET: shows high sensitivity and specificity for recurrent tumours
Differential diagnosis
Imaging differential considerations include:
- consider intracranial metastases from
- leukaemia
- dural or calvarial based masses
- usually associated with intraparenchymal masses
- Ewing sarcoma
- osteosarcoma
- skeletal involvment withlangerhans cell histiocytosis: lytic bone lesions without periosteal bone formation
- extra-axial intracranial haematoma
-<p><strong>Craniocerebral neuroblastoma metastases </strong>usually involve the calvaria, orbits, skull base and the dura.</p><p>Please refer to the article <a href="/articles/neuroblastoma">neuroblastoma</a> for a general discussion on this entity. </p><h4>Clinical presentation</h4><ul>- +<p><strong>Craniocerebral neuroblastoma metastases </strong>usually involve the calvaria, orbits, skull base and the dura.</p><p>Please refer to the article <a href="/articles/neuroblastoma">neuroblastoma</a> for a general discussion on this entity. </p><h4>Clinical presentation</h4><ul>
-<li>sutural separation: non uniform sutural separation with indistinct sutures margins</li>-<li>cranial metastasis nearly always extra-dural (may mimic epidural or subdural hematoma)</li>- +<li>sutural separation: non-uniform sutural separation with indistinct sutures margins</li>
- +<li>cranial metastasis nearly always extradural (may mimic epidural or subdural hematoma)</li>
-<strong>T1 C+ (Gd)</strong>: vigorously enhances, may be heterogeneous</li>- +<strong>T1 C+ (Gd)</strong>: vigorously enhances, may be heterogeneous</li>
-</ul><h4>Differential diagnosis</h4><p>Imaging differential considerations include</p><ul>-<li>consider intracranial metastases from <ul>-<li><a title="leukaemia" href="/articles/leukaemia">leukaemia</a></li>- +</ul><h4>Differential diagnosis</h4><p>Imaging differential considerations include:</p><ul>
- +<li>consider intracranial metastases from<ul>
- +<li><a href="/articles/leukaemia">leukaemia</a></li>
-<li><a title="Ewing sarcoma" href="/articles/ewing-sarcoma">Ewing sarcoma</a></li>-<li><a title="Osteosarcoma" href="/articles/osteosarcoma">osteosarcoma</a></li>- +<li><a href="/articles/ewing-sarcoma">Ewing sarcoma</a></li>
- +<li><a href="/articles/osteosarcoma">osteosarcoma</a></li>
-<li>skeletal involvment with <a href="/articles/langerhans-cell-histocytosis">langerhans cell histiocytosis</a>: lytic bone lesions without periosteal bone formation</li>-<li>extra-axial <a title="Intracranial haemorrhage" href="/articles/intracranial-haemorrhage">intracranial haematoma</a>- +<li>skeletal involvment with <a href="/articles/langerhans-cell-histocytosis">langerhans cell histiocytosis</a>: lytic bone lesions without periosteal bone formation</li>
- +<li>extra-axial <a href="/articles/intracranial-haemorrhage">intracranial haematoma</a>
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