Non-small cell lung cancer
Disclosures
- updated 15 May 2023:
Nothing to disclose
Updates to Article Attributes
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was changed:
Non-small cell lung cancer(NSCLC) represents a heterogeneous group of lung cancers that do not have "small cells" on histology. They are thus separated, as small cell carcinoma of the lung has distinctive management implications. The major histological types include:
Other less common types of non-small cell lung cancers include:
In addition, a new category of preinvasive lesions and and minimally invasive lesions has also been created, as patients in this category will have a favourable response to treatment. This category includes:
atypical adenomatous hyperplasia (AAH)
ofof lungadenocarcinoma in situ (AIS)
ofof the lung (non-mucinous, mucinous, or mixed non-mucinous/mucinous)diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): a precursor lesion to carcinoid tumours
Specific genetic subtypes
Other sutbtypes
All of these entities will be discussed separately in the respective articles.SMARCA4 deficient (d) NSCLC: considered aggressive subtype
-<p><strong>Non-small cell lung cancer</strong> (NSCLC) represents a heterogeneous group of <a href="/articles/lung-cancer-3">lung cancers</a> that do not have "small cells" on histology. They are thus separated, as <a href="/articles/small-cell-lung-cancer-4">small cell carcinoma of the lung</a> has distinctive management implications. The major histological types include:</p><ul>-<li><a href="/articles/adenocarcinoma-of-lung">adenocarcinoma of lung</a></li>-<li><a href="/articles/squamous-cell-carcinoma-of-lung">squamous cell carcinoma of the lung</a></li>-<li><a href="/articles/large-cell-lung-cancer">large cell carcinoma of the lung</a></li>- +<p><strong>Non-small cell lung cancer</strong> (NSCLC) represents a heterogeneous group of <a href="/articles/lung-cancer-3">lung cancers</a> that do not have "small cells" on histology. They are thus separated, as <a href="/articles/small-cell-lung-cancer-4">small cell carcinoma of the lung</a> has distinctive management implications. The major histological types include:</p><ul>
- +<li><p><a href="/articles/adenocarcinoma-of-lung">adenocarcinoma of lung</a></p></li>
- +<li><p><a href="/articles/squamous-cell-carcinoma-of-lung">squamous cell carcinoma of the lung</a></p></li>
- +<li><p><a href="/articles/large-cell-lung-cancer-1">large cell carcinoma of the lung</a></p></li>
-<li><a href="/articles/adenosquamous-carcinoma-of-lung">adenosquamous carcinoma of the lung</a></li>- +<li><p><a href="/articles/adenosquamous-carcinoma-of-lung">adenosquamous carcinoma of the lung</a></p></li>
-<a href="/articles/primary-sarcomatoid-carcinoma-of-the-lung">sarcomatoid carcinoma of the lung</a><ul>-<li>-<a href="/articles/pleomorphic-carcinoma-of-lung">pleomorphic carcinoma of the lung</a> </li>-<li><a href="/articles/spindle-cell-carcinoma-of-lung">spindle cell carcinoma of the lung</a></li>-<li><a href="/articles/giant-cell-carcinoma-of-the-lung">giant cell carcinoma of the lung</a></li>-<li><a href="/articles/lung-carcinosarcoma">carcinosarcoma of the lung</a></li>-<li><a href="/articles/pleuropulmonary-blastoma">pulmonary blastoma</a></li>- +<p><a href="/articles/primary-sarcomatoid-carcinoma-of-the-lung">sarcomatoid carcinoma of the lung</a></p>
- +<ul>
- +<li><p><a href="/articles/pleomorphic-carcinoma-of-lung">pleomorphic carcinoma of the lung</a> </p></li>
- +<li><p><a href="/articles/spindle-cell-carcinoma-of-lung">spindle cell carcinoma of the lung</a></p></li>
- +<li><p><a href="/articles/giant-cell-carcinoma-of-the-lung">giant cell carcinoma of the lung</a></p></li>
- +<li><p><a href="/articles/lung-carcinosarcoma">carcinosarcoma of the lung</a></p></li>
- +<li><p><a href="/articles/pleuropulmonary-blastoma">pulmonary blastoma</a></p></li>
-<li><a href="/articles/carcinoid-tumours-of-the-lung">carcinoid tumours of the lung</a></li>- +<li><p><a href="/articles/carcinoid-tumours-of-the-lung">carcinoid tumours of the lung</a></p></li>
-<a href="/articles/carcinomas-of-the-lung-of-salivary-gland-type">carcinomas of the lung of salivary gland type</a> <sup>6</sup><ul>-<li><a href="/articles/adenoid-cystic-carcinoma-acc-of-lung">adenoid cystic carcinoma (ACC) of lung</a></li>-<li><a href="/articles/mucoepidermoid-carcinoma-mec-of-lung">mucoepidermoid carcinoma (MEC) of lung</a></li>-<li><a href="/articles/epithelial-myoepithelial-carcinoma-of-lung">epithelial-myoepithelial carcinoma of the lung</a></li>- +<p><a href="/articles/carcinomas-of-the-lung-of-salivary-gland-type">carcinomas of the lung of salivary gland type</a> <sup>6</sup></p>
- +<ul>
- +<li><p><a href="/articles/adenoid-cystic-carcinoma-acc-of-lung">adenoid cystic carcinoma (ACC) of lung</a></p></li>
- +<li><p><a href="/articles/mucoepidermoid-carcinoma-mec-of-lung">mucoepidermoid carcinoma (MEC) of lung</a></p></li>
- +<li><p><a href="/articles/epithelial-myoepithelial-carcinoma-of-lung">epithelial-myoepithelial carcinoma of the lung</a></p></li>
-</ul><p>In addition, a new category of <a href="/articles/preinvasive-lesions-of-the-lung">preinvasive lesions</a> and minimally invasive lesions has also been created, as patients in this category will have a favourable response to treatment. This category includes:</p><ul>-<li><a href="/articles/squamous-dysplasia-of-lung">squamous dysplasia of lung</a></li>-<li><a href="/articles/squamous-cell-carcinoma-in-situ-cis-of-lung">squamous cell carcinoma in situ (CIS) of lung</a></li>-<li>-<a href="/articles/atypical-adenomatous-hyperplasia-aah">atypical adenomatous hyperplasia (AAH)</a> of lung</li>-<li>-<a href="/articles/adenocarcinoma-in-situ-of-the-lung">adenocarcinoma in situ (AIS) of the lung</a> (non-mucinous, mucinous, or mixed non-mucinous/mucinous)</li>-<li><a href="/articles/minimally-invasive-adenocarcinoma-of-lung-mia">minimally invasive adenocarcinoma of the lung (MIA)</a></li>-<li>-<a href="/articles/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia">diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)</a>: a precursor lesion to carcinoid tumours</li>-</ul><h6>Specific genetic subtypes</h6><ul><li><a href="/articles/anaplastic-lymphoma-kinase-alk-fusion-oncogene-positive-non-small-cell-lung-cancer-1">anaplastic lymphoma kinase (ALK) fusion oncogene positive non-small cell lung cancer</a></li></ul><p>All of these entities will be discussed separately in the respective articles. </p>- +</ul><p>In addition, a new category of <a href="/articles/preinvasive-lesions-of-the-lung">preinvasive lesions</a> and minimally invasive lesions has also been created, as patients in this category will have a favourable response to treatment. This category includes:</p><ul>
- +<li><p><a href="/articles/squamous-dysplasia-of-lung">squamous dysplasia of lung</a></p></li>
- +<li><p><a href="/articles/squamous-cell-carcinoma-in-situ-cis-of-lung">squamous cell carcinoma in situ (CIS) of lung</a></p></li>
- +<li><p><a href="/articles/atypical-adenomatous-hyperplasia-aah">atypical adenomatous hyperplasia (AAH)</a> of lung</p></li>
- +<li><p><a href="/articles/adenocarcinoma-in-situ-of-the-lung">adenocarcinoma in situ (AIS) of the lung</a> (non-mucinous, mucinous, or mixed non-mucinous/mucinous)</p></li>
- +<li><p><a href="/articles/minimally-invasive-adenocarcinoma-of-lung-mia">minimally invasive adenocarcinoma of the lung (MIA)</a></p></li>
- +<li><p><a href="/articles/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia">diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)</a>: a precursor lesion to carcinoid tumours</p></li>
- +</ul><h6>Specific genetic subtypes</h6><ul><li><p><a href="/articles/anaplastic-lymphoma-kinase-alk-fusion-oncogene-positive-non-small-cell-lung-cancer-1">anaplastic lymphoma kinase (ALK) fusion oncogene positive non-small cell lung cancer</a></p></li></ul><h6>Other sutbtypes</h6><ul><li><p><a href="/articles/smarca4-deficient-d-nsclc" title="SMARCA4 deficient (d) NSCLC">SMARCA4 deficient (d) NSCLC</a>: considered aggressive subtype</p></li></ul>
References changed:
- 7. Yadav R, Sun L, Salyana M, Eric M, Gotlieb V, Wang J. SMARCA4-Deficient Undifferentiated Tumor of Lung Mass-A Rare Tumor With the Rarer Occurrence of Brain Metastasis: A Case Report and Review of the Literature. J Investig Med High Impact Case Rep. 2022;10:23247096221074864. <a href="https://doi.org/10.1177/23247096221074864">doi:10.1177/23247096221074864</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/35356840">Pubmed</a>
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